OPTIMIZATION OF THE METHOD OF ULTRASONIC EXTRACTION OF BIOLOGICALLY ACTIVE COMPOUNDS WITH AN ALCOHOL-WATER MIXTURE FROM THE FRUITS OF VACCINIUM VITIS-IDAEA L., GROWING ON THE KOLA PENINSULA

UDK 66.061.34

  • Lidiya Nikolaevna Sereda Laboratory for Medical and Biological Technologies, Nanomaterials Research Centre, Federal Research Center Kola Scientific Center RAS Email: sundukpandory87@mail.ru
  • Nikita Sergeevich Tsvetov Institute of Chemistry and Technology of Rare Elements and Mineral Raw Materials named after I.V. Tananaeva Federal Research Center Kola Scientific Center RAS Email: n.tsvetov@ksc.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20240113108
Keywords: Vaccinium vitis-idaea L., fruits, ultrasound-assisted extraction, optimization, biologically active substances, Arctic

Abstract

Lingonberry (Vaccinium vitis-idaea L.) is a profusely fruiting evergreen berry shrub, which is a hypoactic forest species, growing throughout the Kola Peninsula. Fruits have a number of significant therapeutic properties, such as antioxidant, antitumor, neuroprotective, decongestant, antibiotic, due to a significant content of phenolic compounds. The process of complete extraction of polyphenolic components from a complex plant matrix requires the development of extraction conditions aimed at maximum mass transfer of target components with minimal destruction of compounds. In connection with the prospects of using the fruits of lingonberry plants in the pharmaceutical and cosmetology industries, in this work, for the first time, optimization of the conditions of the method of ultrasonic extraction with a water-ethanol mixture using single-factor analysis and the Box-Benken algorithm was carried out. The kinetics of the extraction process is approximated by the second-order reaction equation. The optimal duration of extraction, the concentration of the extractant, the power of ultrasonic exposure, the diameter of the fractions of plant raw materials, the hydromodule and the extraction temperature were determined. The total content of polyphenols and antioxidant activity, as well as the degree of inhibition of free radicals, were determined. The results obtained can be used in the development of technologies for the production of components for use in the pharmaceutical and cosmetology industries.

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Author Biographies

Lidiya Nikolaevna Sereda, Laboratory for Medical and Biological Technologies, Nanomaterials Research Centre, Federal Research Center Kola Scientific Center RAS

junior researcher at the Laboratory of Medical and Biological Technologies

Nikita Sergeevich Tsvetov, Institute of Chemistry and Technology of Rare Elements and Mineral Raw Materials named after I.V. Tananaeva Federal Research Center Kola Scientific Center RAS

Candidate of Chemical Sciences, researcher

References

Ramenskaya M.L. Analiz flory Murmanskoy oblasti i Karelii. [Analysis of the flora of the Murmansk region and Kare-lia]. Leningrad, 1983, 216 p. (in Russ.).

Kowalska K. International Journal of Molecular Sciencesб 2021, vol. 22, no. 10, article 5126. DOI: 10.3390/ijms22105126

Vilkickyte G., Petrikaite V., Pukalskas A., Sipailiene A., Raudone L. Journal of Ethnopharmacology, 2022, vol. 292, article 115207. DOI: 10.1016/j.jep.2022.115207.

Vilkickyte G., Petrikaite V., Marksa M., Ivanauskas L., Jakstas V., Raudone L. Antioxidants, 2023, vol. 12, no. 2, arti-cle 465. DOI: 10.3390/antiox12020465.

Grace M.H., Esposito D., Dunlap K.L., Lila M.A. Journal of agricultural and food chemistry, 2014, vol. 62, no. 18, pp. 4007–4017. DOI: 10.1021/jf403810y.

Szakiel A., Pączkowski C., Koivuniemi H., Huttunen S. Journal of Agricultural and Food Chemistry, 2012, vol. 60, no. 19, pp. 4994–5002. DOI: 10.1021/jf300375b.

Dróżdż P., Šėžienė V., Wójcik J., Pyrzyńska K. Molecules, 2017, vol. 23, no. 1, article 53. DOI: 10.3390/molecules23010053

Dincheva I., Badjakov I. International Journal of Medicine and Pharmaceutical Science, 2016, vol. 6, no. 3, pp. 39–50.

Bujor O-C., Ginies C., Popa V. I., Dufour C. Food chemistry, 2018, vol. 252, pp. 356–365. DOI: 10.1016/j.foodchem.2018.01.052.

Makarova N.V., Yeremeyeva N.B. Khimiya Rastitel'nogo Syr'ya, 2020, no. 1, pp. 167–177. DOI: 10.14258/jcprm.2020014425. (in Russ.).

Matveeva V.I., Ruchkina A.G., Kobrakov K.I., Shpigun L.K., Shmakova N.S. Khimiya Rastitel'nogo Syr'ya, 2022, no. 2, pp. 105–112. DOI: 10.14258/jcprm.20220210516. (in Russ.).

Vrancheva R., Ivanov I., Badjakov I., Dincheva I., Georgiev V., Pavlov A. Food Science and Applied Biotechnology, 2020, vol. 3, no. 2, pp. 149–156. DOI: 10.30721/fsab2020.v3.i2.98.

Zhu Y., Yu J., Jiao C., Tong J., Zhang L., Chang Y., Sun W., Jin Q., Cai Y. Heliyon, 2019, vol. 5, no. 9. DOI: 10.1016/j.heliyon.2019.e02374.

Bitwell C., Indra S.S., Luke C., Kakoma M.K. Scientific African, 2023, vol. 19, no. 5, article e01585. DOI: 10.1016/j.sciaf.2023.e01585.

Beydeman I.N. Metodika fenologicheskikh nablyudeniy pri geobotanicheskikh issledovaniyakh. [Methodology for phe-nological observations in geobotanical research]. Moscow, Leningrad, 1954, 130 p. (in Russ.).

Meier U., Bleiholder H., Buhr L., Feller C., Hacks H., Hess M., Lancashire P.D., Schnock U., Stauss R., van den Boom T., Weber E., Zwerger P. Journal für Kulturpflanzen, 2009, vol. 61, pp. 41–52. DOI: 10.5073/JfK.2009.02.01.

Meier U. Growth stages of mono- and dicotyledonous plants BBCH. Quedlinburg, 2018, 204 p. DOI: 10.5073/20180906-074619.

Gosudarstvennaya farmakopeya Rossiyskoy Federatsii, XIV izd. [State Pharmacopoeia of the Russian Federation, XIV ed.]. Moscow, 2018, vol. 1, pp. 272–275. (in Russ.).

Tungmunnithum D., Garros L., Drouet S., Renouard S., Lainé E., Hano C. Plants, 2019, vol. 8, no. 3, article 50. DOI: 10.3390/plants8030050.

Cavdarova M., Makris D.P. Waste and Biomass Valorization, 2014, vol. 5, pp. 773–779. DOI: 10.1007/s12649-014-9298-3.

Tsvetov N., Sereda L., Korovkina A., Artemkina N., Kozerozhets I., Samarov A. Biomass Conversion and Biorefinery, 2022, vol. 12, pp. 145–156. DOI: 10.1007/s13399-022-02299-2.

Published
2024-03-06
How to Cite
1. Sereda L. N., Tsvetov N. S. OPTIMIZATION OF THE METHOD OF ULTRASONIC EXTRACTION OF BIOLOGICALLY ACTIVE COMPOUNDS WITH AN ALCOHOL-WATER MIXTURE FROM THE FRUITS OF VACCINIUM VITIS-IDAEA L., GROWING ON THE KOLA PENINSULA // chemistry of plant raw material, 2024. № 1. P. 292-300. URL: http://journal.asu.ru/cw/article/view/13108.
Issue
No 1 (2024)
Section
Low-molecular weight compounds

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