CHROMATOGRAPHIC AND SPECTRAL STUDY OF ARCTIUM LAPPA AND ARCTIUM TOMENTOSUM FRUCTUS CULTIVATED IN ALTAI:

Наталья Эдуардовна Коломиец; Роман Сергеевич Боев; Людмила Владимировна  Жалнина; Абдуджалил Каид Хасан Али

doi:10.14258/jcprm.20240112476

Наталья Эдуардовна Коломиец Сибирский государственный медицинский университет; Кемеровский государственный медицинский университет Email: borkol47@mail.ru
Роман Сергеевич Боев ООО "Вистерра" Email: brs-0@yandex.ru
Людмила Владимировна Жалнина Siberian State Medical University Email: zhalnina82@gmail.com
Абдуджалил Каид Хасан Али Siberian State Medical University Email: jalilalshemiry@yahoo.com

https://doi.org/10.14258/jcprm.20240112476

Ключевые слова: cultivate, burdock fructus, methyl-cis-9,cis-15-octadecadienoate, 11-eicosenoic acid methyl ester, hydroxycinnamic acid, anthocyanin’s

Аннотация

Burdock is an ingredient of official and traditional medicines in different countries, its roots are used for food, biologically active additives, functional nutrition products, fertilizers, etc. A great demand led to the situation when many countries including Russia began the plant’s cultivation. Despite that, the aboveground parts of the plant including its fructus still remain expendable. At the moment, burdock fructus are officially used only in China and Japan. In Russia they are not used and studies of their chemical composition and pharmacological properties are scarce.

The research showed that fructus of Arctium lappa and A. tomentosum cultivated in Altai using by traditional way of growing, and new of agrotechnics of cultivation contain lignans, hydroxycinamic acid, fatty acids and their derivatives, polysaccharides and anthocyanin’s. The use of a new cultivation technology increased the content of lignans and other BAS by 10–25%. Hydroxycinamic acid is one of the dominant substances in fructus by content, therefore it is possible to standardize raw material according to this parameter. The presence of methyl cis-9, cis-15-octadecadienoate and 11-Eicosenoic acid methyl ester in fructushas been discovered for the first time. Ethyl linoleate and methylfolate or methyl cis-9-octadecenoate are found to be dominant components of fatty acids and their derivatives.

Additional studies of chemical composition, pharmacological properties, clinical approbation are needed to obtain evidence of the efficiency of burdock fructus utilization for clinical purposes and prevention.

Скачивания

Данные скачивания пока недоступны.

Metrics

Загрузка метрик ...

Биографии авторов

Наталья Эдуардовна Коломиец, Сибирский государственный медицинский университет; Кемеровский государственный медицинский университет

доктор фармацевтических наук, профессор кафедры фармацевтического анализа; профессор кафедры фармации

Роман Сергеевич Боев, ООО "Вистерра"

кандидат фармацевтических наук, директор ООО "Вистерра"

Людмила Владимировна Жалнина, Siberian State Medical University

аспирант кафедры фармацевтического анализа

Абдуджалил Каид Хасан Али, Siberian State Medical University

аспирант кафедры фармацевтического анализа

Литература

Arctium. The Plant List. Version 1.1. 2013.

Rastitel'nyye resursy Rossii. Dikorastushchiye tsvetkovyye rasteniya, ikh komponentnyy sostav i biologicheskaya ak-tivnost'. T. 5. Semeystvo Asteraceae (Compositae). Ch. 1. Rody Achillea–Doronicum. [Plant resources of Russia. Wild flowering plants, their component composition and biological activity. Vol. 5. Family Asteraceae (Compositae). Part 1. Genera Achillea–Doronicum]. Moscow, 2012, 320 р. (in Russ.).

Sokolov S.Ya. Spravochnik po lekarstvennym rasteniyam [Handbook of Medicinal Plants]. Moscow, 1990, 464 p. (in Russ.).

Sobolevskaya K.A. et al. Poleznyye rasteniya Zapadnoy Sibiri i perspektivy ikh introduktsii. [Useful plants of Western Siberia and prospects for their introduction]. Novosibirsk, 1972, 58 p. (in Russ.).

Gun G. Asian Journal of Pharmaceutical and Clinical Research, 2019, vol. 12, no. 7, pp. 53–59. DOI: 10.22159/ajpcr.2019.v12i7.33870.

Wang D., Bădărau A.S., Swamy M.K. et al. Front Plant Sci., 2019, vol. 10, article 834. DOI: 10.3389/fpls.2019.00834.

Kolomiets N.E., Boev R.S., Zhalnina L.V. et al. Khimiya Rastitel'nogo Syr'ya, 2021, no. 2, pр. 29–57. DOI: 10.14258/jcprm.2021028315. (in Russ.).

Kolomiets N.E., Korolev S.A., Isaykina N.V. et al. Pharmacogn J., 2021, vol. 13, no. 6, pр. 1734–1745. DOI: 10.5530/pj.2021.13.224.

Adham A.N., Hegazy M.E.F., Naqishbandi A.M., Efferth T. Molecules, 2020, vol. 25, no. 21, article 5016. DOI: 10.3390/molecules25215016.

Kuo D.-H., Hung M.-C., Hung C.-M. et al. Food Chem., 2012, vol. 134, no. 3, pp. 1320–1326. DOI: 10.1016/j.foodchem.2012.03.023.

Ming D.S., Guns E.S., Eberding A., Towers G.H.N. Pharm Biol., 2004, vol. 42, pp. 44–48. DOI: 10.5650/jos.54.589.

Povet'yeva T.N., Pashinskiy V.G., Kanakina T.A. Rastitel'nyye resursy, 1998, no. 34(2), pp. 57–65. DOI: 10.1080/13880200490505474. (in Russ.).

Os'kina O.A., Pashinskii V.G., Kanakina T.A. et al. Eksperimental'naya i klinicheskaya farmakologiya, 1999, no. 62(4), p. 39. (in Russ.).

Zhou X., Zhang H., Ge L., Gong H., Tian S. J. Chem., 2011, vol. 8, pp. 372–377.

Kharlamov I.A., Khazanovich R.L., Khalmatov Kh.Kh. Chem. of Nat. Comp., 1967, vol. 3, no. 5, p. 295. DOI: 10.1155/2011/517681.

Yakhontova L.D., Kibal'chich P.N. Chem. of Nat. Comp., 1971, vol. 7, no. 3, pp. 287–288. DOI: 10.1007/BF00574642.

Ul'chenko N.T., Bekker N.P., Glushenkova A.I. Chem. of Nat. Comp., 2008, vol. 44, no. 2, pp. 147–150. DOI: 10.1007/BF00569000.

Kharlamov I.A., Khazanovich P.L., Khalmatov Kh.Kh. Farmatsiya, 1968, no. 17(3), pp. 45–49. DOI: 10.1007/s10600-008-9002-6. (in Russ.).

Saleh N.A.M., Bohm B.A. Experientia, 1971, vol. 27, no. 12, p. 1494.

Morris L.J., Marshall M.O., Hammond E.W. Lipids, 1968, vol. 3, no. 1, pp. 91–95. DOI: 10.1007/BF02154314.

Tsevegsüren N., Aitzetmüller K., Vosmann K. Lipids, 1999, vol. 34, no. 5, pp. 525–529. DOI: 10.1007/BF02530976.

Ul'chenko N.T., Gigienova E.I., Umarov A.U., Isamukhamedov A.Sh. Chem. of Nat. Comp., 1981, vol. 17, no. 1, pp. 26–30. DOI: 10.1007/s10600-008-9002-6.

Ucciani E., Mallet G., Gamisans J., Gruber M. Grasas y Aceites, 1994, vol. 45, no. 3, pp. 107–112. DOI: 10.3989/gya.1994.v45.i3.981.

Ge L., Liu F., Hu Y., Zhou X. J. of Planar Chromatogr – Modern TLC, 2020, vol. 33(1), pp. 19–26. DOI: 10.1007/s00764-019-00005-z.

Kopyt'ko Ya.F., Kir'yanov A.A., Stikhin Yu.V. Khimiko-farmatsevticheskiy zhurnal, 2003, no. 6, pp. 46–47. (in Russ.).

Ferracane R., Graziani G., Gallo M., Fogliano V., Ritieni A. J. of Pharm. and Biomed. Analysis, 2010, vol. 51, no. 2, pp. 399–404. DOI: 10.1016/j.jpba.2009.03.018.

Liu J., Cai Y.-Z., Wong R.N.S. et al. J. of Agric. and Food Chemistry, 2012, vol. 60, no. 16, pp. 4067–4075. DOI: 10.1021/jf2050697.

He J., Huang X.-Y., Yang Y.-N. et al. J. of Asian Natur. Prod. Research, 2016, vol. 18, no. 5, pp. 423–428. DOI: 10.1080/10286020.2016.1145671.

Kolomiets N.E., Kalinkina G.I., Sapronova N.N. Farmatsiya, 2011, no. 6, pp. 22–24. (in Russ.).

Gosudarstvennaya farmakopeya RF, XIV izd. [State Pharmacopoeia of the Russian Federation, XIV ed.]. Moscow, 2018. URL: http://resource.rucml.ru/feml/pharmacopia/14_4/HTML/index.html. (in Russ.).

Belyakov K.V., Popov D.M. Farmatsiya, 1998, no. 1, pр. 34–36. (in Russ.).

Chan Y.-Sh., Cheng L.-N., Wu J.-H. et al. Inflammopharmacology, 2011, vol. 19, no. 5, pp. 245–254.