IN VITRO ANTIOXIDANT AND ANTIRADICAL ACTIVITY OF THE TOTAL POLYPHENOLS (SUBSTANCES OF THE ANTIVIRAL DRUG RUTAN) OF THE LEAVES OF TANNIC SUMACH RHUS CORIARIA L.

UDC 581.19:634.776

  • Tahir Fatikhovich Aripov Institute of Bioorganic Chemistry. acad. A.S. Sadykov Academy of Sciences of the Republic of Uzbekistan Email: aripov_takhir@mail.ru
  • Ulugbek Gapparzhanovich Gayibov Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: gayibov.ulugbek@gmail.com
  • Sabina Narimonovna Gayibova Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: gayibova.sabina@gmail.com
  • Azizbek Akbar ugli Abdullaev Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: dr.abdullaev.scientist@gmail.com
  • Dildora Sharifzhon kizi Abduazimova Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: abduazimovadildora12@gmail.com
  • Yulia Igorevna Oshchepkova Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: joshepkova05@rambler.ru
  • Shavkat Ismailovich Salikhov Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan Email: joshepkova05@rambler.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.20240413433
Keywords: Rhus coriaria L., polyphenols, antioxidant activity, antiradical activity, diphenylpicrylhydrazyl, DPPH

Abstract

As a result of the study of antiradical and antioxidant activities under in vitro conditions, it was determined that Rutan has a high antiradical activity to the free radical DPPH, it is a verified antioxidant, the mechanism of action of which is the release of transportable hydrogen to the free radical, resulting in the chain termination of the peroxidation reaction lipids (LPO). This fact is also confirmed by the correlation coefficient r=0.94 between the manifestation of antioxidant and antiradical properties. In experiments on the ability to inhibit the opening of mPTP, it was shown that Rutan has a protective effect on mitochondrion, depending on the concentration, reducing the damaging effect of Ca2+ ions on the process of mPTP opening and is an effective regulator and modifier of the CsA-sensitive mitochondrion pore. Additionally, Rutan affects the activity of the ATP-dependent potassium channel and the enzyme-cardiomarker – creatine kinase, thereby possessing a cardioprotective mechanism and preserving the vital activity of myocardial cells.

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Author Biographies

Tahir Fatikhovich Aripov , Institute of Bioorganic Chemistry. acad. A.S. Sadykov Academy of Sciences of the Republic of Uzbekistan

Doctor of Biological Sciences, Professor, Academician, Head of the Laboratory of Plant Cytoprotectors

Ulugbek Gapparzhanovich Gayibov , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

PhD, Senior Researcher

Sabina Narimonovna Gayibova , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

PhD, Senior Researcher

Azizbek Akbar ugli Abdullaev , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

Junior Researcher

Dildora Sharifzhon kizi Abduazimova , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

Junior Researcher

Yulia Igorevna Oshchepkova , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

Doctor of Chemical Sciences, Professor, Deputy Director for Science

Shavkat Ismailovich Salikhov , Institute of Bioorganic Chemistry named after Academician A.S. Sadykov of the Academy of Sciences of the Republic of Uzbekistan

Doctor of Biological Sciences, Academician, Head of the Laboratory of Chemistry of Proteins and Peptides

References

Aktivatsiya svobodnoradikal'nogo okisleniya – efferentnoye zveno tipovykh patologicheskikh protsessov [Activation of free radical oxidation – an efferent link of typical pathological processes], ed. N.P. Chesnokova, M.Yu. Ledvanov. Sa-ratov, 2006, 177 p. (in Russ.).

Chesnokova N.P., Morrison V.V., Ponukalina Ye.F., Afanas'yeva G.A., Bizenkova M.N., Barsukov V.Yu., Moro-zova O.L., Polutova N.V., Zhevak T.I. Fundamental'nyye issledovaniya, 2009, no. 5, pp. 122–130. (in Russ.).

García-Sánchez A., Miranda-Díaz A.G., Cardona-Muñoz E.G. Oxid. Med. Cell. Longev., 2020, vol. 2020, 2082145. https://doi.org/10.1155/2020/2082145.

Delgado-Roche L., Mesta F. Arch. Med. Res., 2020, vol. 51, pp. 384–387. https://doi.org/10.1016/j.arcmed.2020.04.019.

Khomich O.A., Kochetkov S.N., Bartosch B., Ivanov A.V. Viruses, 2018, vol. 10, 392. https://doi.org/10.3390/v10080392.

Checconi P., De Angelis M., Marcocci M.E., Fraternale A., Magnani Palamara A.T., Nencioni L. Int. J. Mol. Sci., 2020, vol. 21, 4084. https://doi.org/10.3390/ijms21114084.

Vladimirov Yu.A. Vestnik Rossiyskoy Akademii meditsinskikh nauk, 1998, no. 7, pp. 43–50. (in Russ.).

Rice-Evans C., Miller N., Paganga G. Trends Plant Sci., 1997, vol. 2(4), pp. 152–159.

Pourcel L., Routaboul J.M., Cheynier V., Lepiniec L., Debeaujon I. Trends Plant Sci., 2007, vol. 12(1), pp. 29–36.

Winkel-Shirley B. Curr. Opin. Plant Biol., 2002, vol. 5(3), pp. 218–223.

Suzuki N., Koussevitzky S., Mittler R.O.N., Miller G.A.D. Plant Cell & Environ, 2012, vol. 35(2), pp. 259–270.

Tang J., Diao P., Shu X., Li L., Xiong L. Biomed. Res. Int., 2019, vol. 2019, article 7039802. https://doi.org/10.1155/2019/7039802.

Basu P., Maier C. Pharmacognosy Res., 2016, vol. 8(4), p. 258. https://doi.org/10.4103/0974-8490.188875.

BourBour F., Mirzaei Dahka S., Gholamalizadeh M., Akbari M.E., Shadnoush M., Haghighi M., Taghvaye-Masoumi H., Ashoori N., Doaei S. Nutrients in prevention, treatment, and management of viral infections; special fo-cus on Coronavirus // Arch Physiol. Biochem., 2020, vol. 1, p. 10. https://doi.org/10.1080/13813455.2020.1791188.

Ziyavitdinov Zh.F., Oshchepkova Yu.I., Abdulladzhanova N.G., Salikhov Sh.I. Khimiya rastitel'nogo syr'ya, 2020, no. 1, pp. 133–140. https://doi.org/10.14258/jcprm.2020016316. (in Russ.).

Patent IAP 06574 (UZ). 21.09.2021. (in Russ.).

Salikhov S.I., Abdurakhmonov I.Y., Oshchepkova Y.I. et al. Front. Med., 2023, vol. 10, 1310129. https://doi.org/10.3389/fmed.2023.1310129.

Ibadova G.A., Musabayev E.I., Razhabov I.B., Baynazarov M.M. Biologija va tiʙʙijot muammolari, 2022, no. 4.1 (138), pp. 39–45. (in Russ.).

Ibadova G.A., Musabayev E.I., Razhabov I.B., Kadyrova N.E., Karimov D.A., Baynazarov M.M., Mardonova Kh.A. Zhurnal teoreticheskoy i klinicheskoy meditsiny, 2022, no. 4, pp. 102–104. (in Russ.).

Samatova I.R., Bayzhanov A.K., Khikmatullayeva A.S. Infektsiya. Immunitet i farmakologiya, 2021, no. 4, pp. 90–94. (in Russ.).

Schneider W.C., Hageboom G.H., Pallade G.E. J. Biol. Chem., 1948, vol. 172 (2), pp. 619–635.

Directive 2010/63/EU on the protection of animals used for scientific purposes. September 22, 2010. Official Journal of the European Union, L 276/33- L276/79.

Skulachev V.P. Biokhimiya, 1994, vol. 59, pp. 1910–1912. (in Russ.).

Mathieu M. et. al. Ann. Biol. Clin., 1982, vol. 40, p. 87.

Tirzitis G., Bartosz G. Acta Biochim. Pol., 2010, vol. 57(2), pp. 139–142. https://doi.org/10.18388/abp.2010_2386.

Bartosz G. Adv. Clin. Chem., 2003, vol. 37, pp. 219–292. https://doi.org/10.1016/s0065-2423(03)37010-6.

Lemasters J.J., Nieminen A.L., Qian T., Trost L.C., Herman B. Mol. Cell. Biochem., 1997, vol. 174(1-2), pp. 159–165.

Crompton M. Biochem. J., 1999, vol. 341, pp. 233–249.

Vladimirov Yu.A., Azizova O.A., Deyev A.I., Kozlov A.V. i dr. Itogi nauki i tekhniki. Seriya Biofizika. [Results of sci-ence and technology. Series Biophysics]. Moscow, 1991, vol. 29. (in Russ.).

Akopova O.I., Nosar' V.I., Man'kovskaya I.N., Sagach V.F. Ukrainskiy biokhimicheskiy zhurnal, 2013, vol. 85(5), pp. 37–49. (in Russ.).

Rohilla A., Manav A., Rohilla S., Kushnoor A. International Journal of Drug Development & Research, 2012, vol. 4(2), pp. 92–98.

Belova Ye.A., Kavushevskaya N.S., Krivykh Ye.A., Kovalenko L.V. Vestnik NovGU. Ser.: Meditsinskiye nauki, 2022, no. 1(126), pp. 47–51. (in Russ.).

Published
2024-11-13
How to Cite
1. Aripov T. F., Gayibov U. G., Gayibova S. N., Abdullaev A. A. ugli, Abduazimova D. S. kizi, Oshchepkova Y. I., Salikhov S. I. IN VITRO ANTIOXIDANT AND ANTIRADICAL ACTIVITY OF THE TOTAL POLYPHENOLS (SUBSTANCES OF THE ANTIVIRAL DRUG RUTAN) OF THE LEAVES OF TANNIC SUMACH RHUS CORIARIA L. // Chemistry of plant raw material, 2024. № 4. P. 138-147. URL: https://journal.asu.ru/cw/article/view/13433.
Issue
No 4 (2024)
Section
Low-molecular weight compounds

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