INVESTIGATION OF THE BIOCHEMICAL COMPOSITION OF SEEDS AND IN SILICO DETERMINATION OF THE PHARMACOLOGICAL ACTIVITY OF THE COMPONENTS OF SWEET PEPPER OIL
UDC 635.649+636.085.16+621.892.31+544.165
Abstract
The article presents the results of determining the biochemical composition of pepper seeds of the sweet variety "Gift of Moldova" extracted from ripe fruits of plants grown in a suburban area within the city of Astrakhan. The spare nutrients of the seeds are represented by proteins (24.6%), carbohydrates (4.8%), fats (14.2%), fiber (6.8%), the content of ascorbic acid in the seeds is 6%, alkaloids 1.6%. By the method of supercritical fluid extraction from the seeds of the sweet pepper variety "Gift of Moldova", an oil with a yield of 14% was obtained, the fatty acid composition of the oil was determined using the chromatography method. The main components of the oil are linoleic (71.65%), palmitic (13.87%), oleic (9.26%), stearic (3%) acids. Elaidic (1.96%) and hexadecenic (0.26%) acids were also found. For the identified components of seed oil, potential types of pharmacological activity were evaluated using the PASS-online and admetSAR web resources. All the studied components showed weakly expressed antibacterial, antifungal and antiviral properties, some activity against strains of Dengue virus infection transmitted to humans from mosquitoes. Linoleic acid is active against the gram-positive strain of Staphylococcus simulans. Palmitic and stearic acids are active against the low-pathogenic streptococcal bacteria Streptococcus viridans.
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