PROSPECTS FOR THE USE OF PLANTS OF THE GENUS PHELLODENDRON AS A SOURCE OF BIOLOGICALLY ACTIVE SUBSTANCES
UDC 615.45:615.322:582.751.9
Abstract
Search for new species of medicinal plant raw materials, promising for use as a source of biologically active compounds is one of the priority directions of scientific research in the development of effective and safe drugs. Among the representatives of the domestic flora the leafy tree – Phellodendron amurense Rupr. is of interest for research. This plant, along with Phellodendron chinense C.K. Schneid, is the subject of research of scientists from different countries of the world, aimed at identifying phellodendron-specific secondary metabolites and assessing the prospects of their use in therapeutic and prophylactic purposes.
In this connection, the purpose of the present work was to summarise the data of scientific literature on systematics, composition of biologically active substances (BAS) accumulated in different parts of plants of the genus Phellodendron and their pharmacological properties.
The analysis allowed to generalise and systematise the data available today on the chemical composition of Phellodendron amurense and Phellodendron chinense. Particular attention in the article is paid to the issue of establishing the structure of the dominant component of Phellodendron amurense leaves – prenyl flavonoid phellamurin. Along with this, the data on biological activity of secondary metabolites of plants of the genus Phellodendron are given. The questions of standardisation of raw materials are covered.
On the basis of the conducted information analysis it is shown that Phellodendron amurense is a source of obtaining BAS. Phellamurin and other flavonoids with high biological activity are of the greatest interest for study.
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Ma J., Cao W., Liu Q., Yu M., Han L.J. Edinburgh Journal of botany, 2006, vol. 63(2-3), pp. 131–151. https://doi.org/10.1017/S0960428606000515.
Govaerts R., Nic Lughadha E., Black N., Turner R., Paton A. Scientific Data, 2021, vol. 8, 215. https://doi.org/10.1038/s41597-021-00997-6.
Plants of the World Online. URL: https://powo.science.kew.org/.
The World Flora Online (2023): Phellodendron Rupr. URL: http://www.worldfloraonline.org/taxon/wfo-4000029178.
Sosudistyye rasteniya sovetskogo Dal'nego Vostoka [Vascular plants of the Soviet Far East], ed. S.S. Kharkevich. Len-ingrad, 1989, vol. 4, 380 p. (in Russ.).
Nikitenko Ye.A. Plodovodstvo, semenovodstvo, introduktsiya drevesnykh rasteniy, 2017, vol. 20, pp. 126–129. (in Russ.)
Nechayev A.A. Plodovodstvo, semenovodstvo, introduktsiya drevesnykh rasteniy, 2019, vol. 22, pp. 141–144. (in Russ.)
Likhenko N.N., Kapko T.N., Yepanchintseva A.P., Likhenko I.Ye. Trudy po prikladnoy botanike, genetike i selektsii, 2023, vol. 184(1), pp. 33–41. https://doi.org/10.30901/2227-8834-2023-1-33-41. (in Russ.)
Zhivchikova R.I., Zhivchikov A.I. Agrarnyy vestnik Primor'ya, 2019, vol. 1(13), pp. 26–29. (in Russ.)
Nechayev V.A., Nechayev A.A. Sibirskiy lesnoy zhurnal, 2016, no. 1, pp. 64–70. (in Russ.)
Luo Y., Zhang X. Heritage Science, 2021, vol. 9, 85. https://doi.org/10.1186/s40494-021-00560-x.
Seregina P.A., Nesterova N.V., Ovsyannikov A.G., Kharina A.S. Tendentsii razvitiya nauki i obrazovaniya, 2021, no. 71-1, pp. 57–64. https://doi.org/10.18411/lj-03-2021-14. (in Russ.)
Makhrova T.G. Problemy botaniki Yuzhnoy Sibiri i Mongolii, 2021, vol. 20(1), pp. 298–300. https://doi.org/10.14258/pbssm.2021058. (in Russ.)
Japanese Pharmacopoeia XVII: Crude drugs and related drugs, 2016, pp. 1938–1939.
Sun Y., Lenon G.B., Yang A.W.H. Evidence-based complementary and alternative medicine, 2019, 7621929. https://doi.org/10.1155/2019/7621929.
Рharmacopeia of the people’s republic of China, 2005, vol. 1.
Rastitel'nyye resursy Rossii: Dikorastushchiye tsvetkovyye rasteniya, ikh komponentnyy sostav i biologicheskaya ak-tivnost'. T. 3. Semeystva Fabaceae – Apiaceae [Plant resources of Russia: Wild flowering plants, their component com-position and biological activity. Vol. 3. Families Fabaceae - Apiaceae], ed. A.L. Budantsev. St. Petersburg; Moscow, 2010, 601 p. (in Russ.)
Leu C.H., Li C.Y., Yao X., Wu T.S. Chemical & pharmaceutical bulletin, 2006, vol. 54(9), pp. 1308–1311. https://doi.org/10.1248/cpb.54.1308.
Xian X., Sun B., Ye X., Zhang G., Hou P., Gao H. Journal of separation science, 2014, vol. 37(13), pp. 1533–1545. https://doi.org/10.1002/jssc.201400012.
Wu T.S., Hsu M.Y., Kuo P.C., Sreenivasulu B., Damu A.G., Su C.R., Li C.Y., Chang H.C. Journal Nat. Prod., 2003, vol. 66(9), pp. 1207–1211. https://doi.org/10.1021/np030034v.
Naumova O.A. Farmakognosticheskoye issledovaniye plodov barkhata amurskogo s tsel'yu kontrolya kachestva i standartizatsii syr'ya: avtoreferat diss. … kand. farm. nauk. [Pharmacognostic study of Amur cork tree fruits for the purpose of quality control and standardization of raw materials: abstract of diss. Cand. of Pharmaceutical Sciences]. Moscow, 2014, 25 p. (in Russ.)
Zhou H.-Y., Wang D., Cui Zh. Journal of Asian Natural Products Research, 2008, vol. 10(5), pp. 409–413. https://doi.org/10.1080/10286020801966534.
Miyake M., Inaba N., Ayano S., Ozaki Y., Maeda H., Ifuku Y., Hasegawa S. Yakugaku Zasshi, 1992, vol. 112(5), pp. 343–347. https://doi.org/10.1248/yakushi1947.112.5_343.
Kuo P.C., Hsu M.Y., Damu A.G., Su C.R., Li C.Y., Sun H.D., Wu T.S. Planta Medica, 2004, vol. 70(2), pp. 183–185. https://doi.org/10.1055/s-2004-815500.
Chiu C.Y., Li C.Y., Chiu C.C., Niwa M., Kitanaka S., Damu A.G., Lee E.J., Wu T.S. Chemical & pharmaceutical bul-letin, 2005, vol. 53(9), pp. 1118–1121. https://doi.org/10.1248/cpb.53.1118.
Wei L., Nan S.Y., Tao Y.X., Young Y.S., Whan C.C., Ji K.E., Kyoung K.H., Ho K.Y. Natural Product Sciences, 2012, vol. 18(4), pp. 250–253.
Hu Y.M., Su G.H., Sze S.C., Ye W., Tong Y. Biomedical chromatography, 2009, vol. 24(4), pp. 438–453. https://doi.org/10.1002/bmc.1311.
Min Y.D., Kwon H.C., Yang M.C., Lee K.H., Choi S.U., Lee K.R. Archives of pharmacal research, 2007, vol. 30(1), pp. 58–63. https://doi.org/10.1007/BF02977779.
Hesegawa M., Shirato T. Journal of the American Chemical Society, 1953, vol. 75, pp. 5507–5511.
Bodalski T., Lamer E. Acta poloniae pharmaceutica, 1965, vol. 22, pp. 281–284.
Bodalski T., Lamer E. Diss Pharm Pharmacol., 1969, vol. 21, pp. 181–184.
Shevchuk O.I. Khimiya prirodnykh soyedineniy, 1968, no. 2(4), pp. 77–82. (in Russ.)
Grimshaw J., Lamer-Zarawska E. Phytochemistry, 1972, vol. 11, pp. 3273–3274.
Otryashenkova V.E., Glyzin V.I., Shreter G.K. Khimiya prirodnykh soyedineniy, 1976, no. 5, pp. 662–663. https://doi.org/10.1007/BF00565205. (in Russ.)
Otryashenkova V.E. Issledovaniye rasteniy roda Phellodendron kak istochnika biologicheski aktivnykh soyedineniy: avtoreferat. diss. … kand. farm. nauk. [Study of plants of the genus Phellodendron as a source of biologically active compounds: abstract. diss. … candidate of pharmaceutical sciences]. Moscow, 1980, 15 p. (in Russ.)
Glyzin V.I., Bankovskii A.I., Sheichenko V.I., Molodozhnikov M.M. Chemistry of Natural Compounds, 1970, vol. 67, pp. 773–775. https://doi.org/10.1007/BF00565362
Sakai S., Hasegawa M. Phytochemistry, 1974, vol. 13, pp. 303–304.
Sakai S. Applied and environmental microbiology, 1977, vol. 34, no. 5, pp. 500–505.
Wu T.-S. Journal Chinese Chem. Soc., 1979, vol. 26, pp. 25–28.
Shalashvili K.G., Sutiashvili M.G., Alaniya M.D., Kavtaradze N.Sh., Skhirtladze A.V. Chemistry of Natural Com-pounds, 2018, vol. 54, pp. 263–266. https://doi.org/10.1007/s10600-018-2319-x.
Souza M.P., Iracema M., Machado L., Braz-Filho R. Phytochemistry, 1989, vol. 28, pp. 2467–2470. https://doi.org/10.1016/S0031-9422(00)98007-5.
Tokuoka Y., Daigo K., Takemoto T. Yakugaku zasshi, 1975, vol. 95(3), pp. 321–325.
Wu T.-S., Hsu M.-Yu., Damu A. G., Kuo P.-C., Su Ch.-R., Li Ch.-Y., Sun H.-D. Hetrocycles, 2003, vol. 60, pp. 397–404. https://doi.org/10.1002/chin.200324205.
Li X.-H., Zhang W.-J., Qi H.-Y., Shi Y.-P. Canadian Journal of Chemistry, 2009, vol. 87(9), pp. 1218–1221. https://doi.org/10.1139/V09-112.
Wang P.F., Li Y.P., Ding L.Q., Cao S.J., Wang L.N., Qiu F. Molecules, 2019, vol. 24(10), 1851. https://doi.org/10.3390/molecules24101851.
Wang M, Ji T.F., Yang J.B., Su Y.L. Zhong Yao Cai, 2009, vol. 32(2), pp. 208–210.
Yan C., Zhang Y.D., Wang X.H., Geng S.D., Wang T.Y., Sun M., Liang W., Zhang W.Q., Zhang X.D., Luo H. Fitot-erapia, 2016, vol. 113, pp. 132–138. https://doi.org/10.1016/j.fitote.2016.07.020.
Chen M.L., Xian Y.F., Ip S.P., Tsai S.H., Yang J.Y., Che C.T. Planta medica, 2010, vol. 76(14), pp. 1530–1535. https://doi.org/10.1055/s-0030-1249774.
Chan C.O., Chu C.C., Mok D.K., Chau F.T. Analytica chimica acta, 2007, vol. 592(2), pp. 121–131. https://doi.org/10.1016/j.aca.2007.04.016.
Tian H., Ma J.P., Guo T., Xie G.-Yu., Zhang J., Wang Y. Chemistry of Natural Compounds, 2019, vol. 55(3), pp. 563–564. https://doi.org/10.1007/s10600-019-02744-1.
Gray A. I., Bhandari P., Waterman P.G. Phytochemistry, 1988, vol. 27(6), pp. 1805–1808. https://doi.org/10.1016/0031-9422(88)80448-5.
Ryuk J.A., Zheng M.S., Lee M.Y., Seo C.S., Li Y., Lee S.H., Moon D.C., Lee H.W., Lee J.H., Park J.Y., Son J.K., Ko B.S. Archives of pharmacal research, 2012, vol. 35(6), pp. 1045–1054. https://doi.org/10.1007/s12272-012-0612-y.
Cuéllar M.J., Giner R.M., Recio M.C., Máñez S., RíOs, J.L. Fitoterapia, 2001, vol. 72, pp. 221–229. https://doi.org/10.1016/s0367-326x(00)00305-1.
Xian Y.F., Mao Q.Q., Ip S.P., Lin Z.X., Che C.T. Journal Ethnopharmacology, 2011, vol. 137(3), pp. 1425–1430. https://doi.org/10.1016/j.jep.2011.08.014.
Xin L., Tan G.Y., Zhang Q., Zhang Q. Chinese journal of integrative medicine, 2024, vol. 30(4), pp. 379–384. https://doi.org/10.1007/s11655-023-3751-8.
Long J., Song J., Zhong L., Liao Y., Liu L., Li X. Biochimie, 2019, vol. 162, pp. 176–184. https://doi.org/10.1016/j.biochi.2019.04.008.
Ishikawa S., Ogawa Y., Tamaki M., Takashima M., Tajika Y., Moue T., Zhang M., Kusayanagi H., Sunagawa M., Hisamitsu T. In Vivo, 2015, vol. 29(6), pp. 671–677.
Kim J.H., Huh J.E., Baek Y.H., Lee J.D., Choi D.Y., Park D.S. J. Ethnopharmacol., 2011, vol. 134(2), pp. 234–242. https://doi.org/10.1016/j.jep.2010.12.005
Zhang H., Zhang S., Wang W., Wang Q., Kuang H., Wang Q. J. Pharm. Biomed. Anal., 2020, vol. 188, 113336. https://doi.org/10.1016/j.jpba.2020.113336.
Erhan S.-E., Pârvu A.E., Ciorîță A., Putri A.A., Villagrana Molina A.J., Pârvu M., MoȚ A.C. Notulae botanicae horti agrobotanici cluj-napoca, 2023, vol. 51(3), 13306. https://doi.org/10.15835/nbha51313306.
Choi Y.Y., Kim M.H., Han J.M., Hong J., Lee T.H., Kim S.H., Yang W.M. Int. Immunopharmacol., 2014, vol. 19(2), pp. 214–220. https://doi.org/10.1016/j.intimp.2014.01.020.
Park J.I., Shim J.K., Do J.W., Kim S.Y., Seo E.K., Kwon H.J., Lee T.K., Kim J.K., Choi D.Y., Kim C.H. Glycoconj Journal, 1999, vol. 16(3), pp. 247–252. https://doi.org/10.1023/a:1007084506071.
Park S.D., Lai Y.S., Kim C.H. Life Sci., 2004, vol. 75, pp. 2621–2632. https://doi.org/10.1016/j.lfs.2004.03.036.
Xu Y., Ventura S. J. Ethnopharmacol., 2010, vol. 127(1), pp. 196–199. https://doi.org/10.1016/j.jep.2009.09.047
Ghosh R., Graham H., Rivas P., Tan X.J., Crosby K., Bhaskaran S., Schoolfield J., Banu J., Fernandes G., Yeh I.T., Kumar A.P. Anticancer Res., 2010, vol. 30(3), pp. 857–865.
James M.A., Fu H., Liu Y., Chen D.R., You M. Mol. Carcinog., 2011, vol. 50(1), pp. 1–7. https://doi.org/10.1002/mc.20690.
Tian X., Xu Z., Hu P., Yu Y., Li Z., Ma Y., Chen M., Sun Z., Liu F., Li J., Huang C. J. Ethnopharmacol., 2020, vol. 263. 113215. https://doi.org/10.1016/j.jep.2020.113215.
Patent 2505310 (RU). 2014. (in Russ.).
Jung H.W., Kim K.H., Park Y.K. Chinese Journal of Integrative Medicine, 2017, vol. 23(10), pp. 755–762. https://doi.org/10.1007/s11655-016-2094-5.
Vichkanova S.A., Kolkhir V.K., Sokol'skaya T.A., Voskoboynikova I.V., Bykov V.A. Lekarstvennyye sredstva iz rasteniy (Opyt VILAR): nauchnoye izdaniye. [Medicines from plants (VILAR experience): scientific publication]. Mos-cow, 2009, pp. 305–315. (in Russ.).
Fateyeva T.V., Deryabin P. G., Bortnikova V.V., Krepkova L.V., Mizina P.G. Byulleten' eksperimental'noy biologii i meditsiny, 2019, vol. 167, no. 4, pp. 463–466. (in Russ.).
Chen H.-Y., Wu T.-S., Wang J.-P., Kuo Sh.-Ch., Chao P.-D.L. The Chinese Pharmaceutical Journal, 2001, vol. 53, pp. 37–44.
Chen H.-Y., Wu T.-S., Hou Y.-C., Kuo S.-C., Chao P.-D.L. Journal of food and drug analysis, 2001, vol. 9(3), article 3. https://doi.org/10.38212/2224-6614.2787.
Chen H.-Y., Wu T.-Sh., Su Sh.-F., Kuo Sh.-Ch., Chao P.-D. L. Planta Med., 2002, vol. 68(2), pp. 138–141. https://doi.org/10.1055/s-2002-20244
Kumar A.P., Bhaskaran S., Ganapathy M., Crosby K., Davis M.D., Kochunov P., Schoolfield J., Yeh I.T., Troy-er D.A., Ghosh R. Clinical cancer research, 2007, vol. 13, pp. 2784–2794. https://doi.org/10.1158/1078-0432.CCR-06-2974
Garcia G.E., Nicole A., Bhaskaran S., Gupta A., Kyprianou N., Kumar A.P. Neoplasia, 2006, vol. 8, pp. 523–533. https://doi.org/10.1593/neo.05745.
Yan G., Lanza-Jacoby S., Wang C. Nutrition and cancer, 2014, vol. 66, pp. 506–516. https://doi.org/10.1080/01635581.2013.780627.
Mukai R. Bioscience, biotechnology, and biochemistry, 2018, vol. 82(2), pp. 207–215. https://doi.org/10.1080/09168451.2017.1415750
Arung E.T., Shimizu K., Tanaka H., Kondo R. Fitoterapia, 2010, vol. 81(6), pp. 640–643. https://doi.org/10.1016/j.fitote.2010.03.011.
Arung E.T., Shimizu K., Kondo R. Chemistry & biodiversity, 2007, vol. 4(9), pp. 2166–2171. https://doi.org/10.1002/cbdv.200790173
Kretzschmar G., Zierau O., Wober J., Tischer S., Metz P., Vollmer G. The Journal of steroid biochemistry and mo-lecular biology, 2010, vol. 118(1-2), pp. 1–6. https://doi.org/10.1016/j.jsbmb.2009.08.005.
Mukai R., Fujikura Y., Murota K., Uehara M., Minekawa S., Matsui N., Kawamura T., Nemoto H., Terao J. Journal Nutr., 2013, vol. 143(10), pp. 1558–1564. https://doi.org/10.3945/jn.113.176818
Konishi Y., Hitomi Y., Yoshida M., Yoshioka E. Journal of agricultural and food chemistry, 2005, vol. 53(26), pp. 9928–9933. https://doi.org/10.1021/jf051962y.
Van de Schans M.G., Bovee T.F., Stoopen G.M., Lorist M., Gruppen H., Vincken J.P. Journal of agricultural and food chemistry, 2015, vol. 63(49), pp. 10628–10640. https://doi.org/10.1021/acs.jafc.5b04703.
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