OBTAINING AND STUDYING HYDROGELS BASED ON CARBOXYMETHYLCELLULOSE
UDC 544.773.432:547.458.82
Abstract
The physicochemical properties (pH, electrical conductivity, relative viscosity, and surface tension) of carboxymethylated wood the paper studies the synthesis of polymer hydrogels based on carboxymethyl cellulose (CMC) using citric, malic, and lactic acids as cross-linking agents. Particular attention is paid to the influence of cross-linking conditions on the formation of the hydrogel structure and changes in the rheological properties of the reaction systems during synthesis. Samples were prepared with a CMC content from 1.96 to 9.09% by weight, with cross-linking agent concentrations in the range of 0.01–0.94%. The swelling degree, gel fraction, moisture content, swelling kinetics, and sorption capacity were studied, and IR spectra reflecting the features of the cross-linking reaction were recorded. The study of the rheological characteristics made it possible to identify the relationship between the degree of cross-linking and the viscoelastic properties of the systems, which is important for monitoring the hydrogel formation process. The optimal synthesis conditions were determined to be 4.76% CMC and 0.71% cross-linking agent. Malic acid was found to be the most effective cross-linking agent, providing the greatest stability and reproducibility of the hydrogel structure. IR spectroscopy studies of the products confirmed the predicted directions of chemical transformations. The obtained results facilitate the development of methods for controlling the CMC cross-linking process to create hydrogels with desired physicochemical properties.
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Kozani P.S., Kozani P.S., Hamidi M., Okoro O.V., Eskandani M., Jaymand M. International Journal of Polymeric Ma-terials and Polymeric Biomaterials, 2022, vol. 71, no. 17, pp. 1319–1333. https://doi.org/10.1080/00914037.2021.1962876
Md. Mahamudul Hasan Rumon, Anwarul Azim Akib, Stephen Don Sarkar, Md. Abu Rayhan Khan, Md. Mosfeq Uddin, Dina Nasrin, Chanchal Kumar Roy. ACS Polym. Au., 2024, vol. 4, no. 6, pp. 463–486. https://doi.org/10.1021/acspolymersau.4c00028.
Huaqian Xue, Cong Zhu, Yifan Wang, Qiancheng Gu, Yunyuan Shao, Anqi Jin, Xiaofen Zhang, Lanjie Lei, Yongliang Li. Materials Today Bio., 2025, vol. 32. 101814. https://doi.org/10.1016/j.mtbio.2025.101814.
Li Ching Wong, Cheu Peng Leh, Choon Fu Goh. Carbohydrate Polymers, 2021, vol. 264. 118036. https://doi.org/10.1016/j.carbpol.2021.118036.
Ahmed E.M. Journal of Advanced Research, 2015, vol. 6, no. 2, pp. 105–121. https://doi.org/10.1016/j.jare.2013.07.006.
Sharma P., Sharma M., Agarwal M., Gupta R. Journal of Cleaner Production, 2024, vol. 478, 143990. https://doi.org/10.1016/j.jclepro.2024.143990.
Hongkun Xue, Ping Wang, Lihong Ji, Kaixuan Zhang, Shaoqin Ge, Jiaqi Tan. Journal of Agriculture and Food Re-search, 2025, vol. 24. 102395. https://doi.org/10.1016/j.jafr.2025.102395.
Zhao L., Zhou Y., Zhang J., Liang H., Chen X., Tan H. Pharmaceutics, 2023, vol. 15. 2514. https://doi.org/10.3390/pharmaceutics15102514.
Tsaniatri D.A., Mulia K., Krisanti E.A. E3S Web of Conferences, 2024, vol. 503. 08008. https://doi.org/10.1051/e3sconf/202450308008.
Alavi M., Nokhodchi A. Carbohydrate Polymers, 2020, vol. 227, pp. 1–6. https://doi.org/10.1016/j.carbpol.2019.115349.
Dutta S.D., Patel D.K., Lim K.T. Journal of Biological Engineering, 2019, vol. 55, no. 13, pp. 1–19. https://doi.org/10.1186/s13036-019-0177-0.
Belyakov N.A. (ed.) Enterosorbtsiya. [Enterosorption]. Leningrad, 1991, 336 p. (in Russ.).
Mohammadzadeh F., Golshan M., Haddadi-Asl V. et al. Scientific Reports, 2023, vol. 13. 11900. https://doi.org/10.1038/s41598-023-39241-z
Wong R.S.H., Dodou K. Polymers, 2017, vol. 9, №7. Article 286. https://doi.org/10.3390/polym9070286.
Kanafi N.M., Rahman N.A., Rosdi N.H. Materials Today: Proceedings, 2019, vol. 7, pp. 721–731. https://doi.org/10.1016/j.matpr.2018.12.067
Kazitsyna L.A., Kupletskaya N.B. Primeneniye UF-, IK- i YAMR-spektroskopii v organicheskoy khimii [Application of UV, IR and NMR spectroscopy in organic chemistry]. Moscow, 1971, 240 p. (in Russ.).
Nafeesa M.K., Norizah A.R., Nurul H.R. Materials Today: Proceedings, 2018, pp. 4-5. https://doi.org/10.1016/j.matpr.2018.12.067.
Li J., Mooney D.J. Designing hydrogels for controlled drug delivery // Nature Reviews Materials. 2016, vol. 1, №12. Ar-ticle 16071. https://doi.org/10.1038/natrevmats.2016.71.
Crini G., Lichtfouse E. Environmental Chemistry Letters, 2019, vol. 17, №1, pp. 145–155. https://doi.org/10.1007/s10311-018-0785-9
Ho Y.S., McKay G. Process Biochemistry, 1999, vol. 34, №5, pp. 451-465. https://doi.org/10.1016/S0032-9592(98)00112-5
Wang J., Chen L., Zhang M. Carbohydrate Polymers, 2019, vol. 205, pp. 276-284. https://doi.org/10.1016/j.carbpol.2018.10.087
Benslimane A., Bahlouli I.M., Bekkour K., Hammiche D. Applied Clay Science, 2016, vol. 132–133, pp. 702–710. https://doi.org/10.1016/j.clay.2016.08.026.
Zhang H. et al. Carbohydrate Polymers, 2019, vol. 215, pp. 322-328. DOI: 10.1016/j.carbpol.2019.03.089.
Li M. et al. Journal of Applied Polymer Science, 2020, vol. 137, №15. Article 48542. https://doi.org/10.1002/app.48542.
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