THE TECHNOLOGY OF OBTAINING OF A SUBSTANCE FROM THE WASTE OF PROCESSING OF THE HYPERICUM PERFORATUM GRASS, WHICH POCESS OF GROWTH-STIMULATING ACTIVITY
Abstract
The stage of drying of the mother liquor after extraction of flavonoids by ethyl acetate of the substance "Dry extract of Hypericum perforatum " was developed, on the basis of this the preparation "Zversin" with growth-stimulating activity was developed. It was found that drying of the "Zversin" using a spray dryer is optimal. As a result of the study of the influencing parameters on the drying process, the following mode was selected, which ensures the optimum operation of the dryer with a high yield of the final product: the temperature of the heat-transfer at the inlet of 160–170 °C, the outlet of 60–70 °C, the feed rate of the solution is 5.5 l / h∙m3, the dry residue of the solution is 10-15%.
The influence of the "Zversin" to the germination of seeds, the growth and development of plant seedlings has been studied. On the basis of the obtained results, the technology for the complex processing of St. John's wort has been developed, which allows to obtain substances for the treatment of depressive conditions and plant growth regulator. At the test technology, it was found that the yield of dry extract (content of total hypericins is 0.3%) yielded to 2.0%, "Zversin" (rutoside content is 6%) – yielded to 7% to the weight mass of raw material.
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Kurkin V.A. Farmakognoziya. [Pharmacognosy]. Samara, 2007, pp. 794–799. (in Russ.).
Ryabinina Ye.I., Zotova Ye.Ye., Vetrova Ye.N., Ponomareva N.I., Ilyushina T.N. Khimiya rastitel'nogo syr'ya, 2011, no. 3, pp. 117–121. (in Russ.).
Kurkin V.A., Pravdivtseva O.Ye. Zveroboy: itogi i perspektivy sozdaniya lekarstvennykh sredstv. [John's wort: results and prospects of creating medicines]. Samara, 2008, 127 p. (in Russ.).
Lomachenko N.V., Bashirova R.M. Itogi biologicheskikh issledovaniy Bashkirskogo universiteta za 1998 god. [Results of biological research of the Bashkir University in 1998]. Ufa, 1999, issue 5, pp. 105–108. (in Russ.).
Baser K.H.C., Ozek T., Nuriddinov H.R., Demirci A.B. Chemestry of Natural Compounds, 2002, vol. 38, no. 1, pp. 54–57.
Sovremennaya fitoterapiya. [Modern herbal medicine]. Ed. V. Petrov. Sofia, 1988, 504 p. (in Russ.).
Minayeva V.G. Lekarstvennyye rasteniya Sibiri. [Medicinal plants of Siberia]. Novosibirsk, 1991, 235 p. (in Russ.).
Patent 4898891 (US). 1990.
Vasil'chenko V.A., Vasil'yeva L.N., Komissarenko N.F. et al. Rastitel'nyye resursy, 1986, vol. 22, issue 1, pp. 12–21. (in Russ.).
Rastitel'nyye resursy SSSR: Tsvetkovyye rasteniya, ikh khimicheskiy sostav, ispol'zovaniye; Semeystva Paeoniaceae – Thymelaeceae. [Plant resources of the USSR: Flowering plants, their chemical composition, use; Family Paeoniaceae – Thymelaeceae]. Leningrad, 1991, vol. 2, pp. 11. (in Russ.).
Demisch L., Holzl J., Gollink B., Kaczmarryk P. Pharmacopsychiatry, 1989, vol. 22, no. 5, pp. 194.
Abu Zakher Kkhaled. Provizor, 2003, no. 10, pp. 23–27. (in Russ.).
Kortikov V.N., Kortikov A.V. Lekarstvennyye rasteniya. [Medicinal plants]. Moscow, 1999, pp. 213–216. (in Russ.).
Kucherov Ye.V., Lazareva D.N., Desyatkin V.K. Lekarstvennyye rasteniya Bashkirii: ikh ispol'zovaniye i okhrana. [Me-dicinal plants of Bashkiria: their use and protection]. Ufa, 1989, pp. 86–90. (in Russ.).
Lovkova M.L., Rabinovich A.M., Buzuk T.N. et al. Pochemu rasteniya lechat. [Why do plants heal]. Moscow, 1989, 252 p. (in Russ.).
Khalmatov Kh.Kh., Kharlamov I.A., Alimov KH.I. et al. Tezisy dokladov 2 s"yezda farmatsevtov Uzbekistana. [Theses of reports 2 congress of pharmacists of Uzbekistan]. Tashkent, 1982, pp. 105–106. (in Russ.).
Vays R.F., Fantel'mann F. Fitoterapiya: Rukovodstvo. [Herbal Medicine: A Guide]. Moscow, 2004, 534 p. (in Russ.).
Muller W.E., Singer A., Wonnemann M. Pharmacopsychiatrry, 2001, vol. 34, no. 1, pp. 98–102.
Belikov V.V., Tochkova T.V., Shatunova L.V., Kolesim N.T., Bayandina I.I. Rastititel'nyye resursy, 1990, vol. 26,
issue 4, pp. 571–578. (in Russ.).
Abu Zakher Kkhaled. Provizor, 2003, no. 10, pp. 23–27. (in Russ.).
Drozdov A.L., Belenova I.A., Leposhkin F.D., Krutikova A.F., Ustinovich K.B., Pokrovskiy O.I., Parenago O.O., Sverkhkriticheskiye flyuidy: Teoriya i Praktika, 2012, vol. 7, no. 4, pp. 59–71. (in Russ.).
Spisok pestitsidov i agrokhimikatov, razreshennykh dlya primeneniya v sel'skom khozyaystve respubliki Uzbekistan. [List of pesticides and agrochemicals permitted for use in agriculture of the Republic of Uzbekistan]. Tashkent, 2013, 321 p. (in Russ.).
Shapoval O.A., Mozharova I.P., Korshuno A.A. Zashchita i karantin rasteniy, 2014, no. 6, pp. 16–20. (in Russ.).
Patent 2004129179/15 (RU). 2006. (in Russ.).
Turayeva S.M., Kuchkarova N.N., Mukhamedov N.S., Mamatkulova N.M. Uzbekskiy biologicheskiy zhurna, 2014, no. 3, pp. 3–7. (in Russ.).
Dospekhov B.A. Metodika polevogo opyta. [Methods of field experience]. Moscow, 1985, pp. 160–164. (in Russ.).
Rakitina YU.V., Rudnik V.Ye. Metody opredeleniya regulyatorov rosta i gerbitsidov. [Methods for determining growth regulators and herbicides]. Leningrad, 1966, pp. 182–197. (in Russ.).

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