THE ELEMENTAL COMPOSITION STUDY OF PLANTS IN THE SIBERIAN FLORA (ALFREDIA CERNUA AND FILI-PENDULA ULMARIA), EXTRACTS AND FRACTIONS TO CREATE DRUGS BASED ON THEM
Abstract
Using the methods of arc atomic emission spectrometry (AAES), atomic emission flame photometry (AEFP), atomic absorption spectrometry (AAS) and mass spectrometry (ICP-MS), the elemental composition of the aerial part of widely used in medical practice Alfredia cernua and Filipendula ulmaria, extracts and fractions obtained from them, is investigated. It was shown that not only biologically active substances, but also mineral elements are extracted by extractants, which may be due both to the formation of complexes with biologically active substances and affinity for extractants. Therefore, the elemental composition must be considered as an important component of plant extracts and medicinal products obtained from them. Simultaneously with biologically active substances in ethanol extracts there is an accumulation of not only biogenic, but also toxic elements, which degree of extraction is often higher. It increases even more during the transition from periodic to countercurrent extraction, which allows to obtain extracts with the highest yield of biologically active substances. Since the enriched extract is directly used to obtain the dosage form, a preliminary elemental analysis is necessary. Analytical control of the content of TM is also necessary when choosing the place of growth of plants raw materials, which are used to create medicinal herbal remedies.
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References
Arceusz A., Radecka I., Wesolowski M. Food chemistry, 2010, vol. 120, no. 1, pp. 52–58.
Afanas'yeva O.G., Suslov N.I., Shilova I.V. Byulleten' eksperimental'noy biologii i meditsiny, 2013, vol. 155, no. 2, pp. 167–169. DOI: 10.1007/s10517-013-2113-5 (in Russ.).
Afanas'yeva O.G., Suslov N.I., Shilova I.V. Byulleten' eksperimental'noy biologii i meditsiny, 2012, vol. 154, no. 8, pp. 188–191. DOI: 10.1007/s10517-012-1918-y (in Russ.).
Suslov N.I., Shilova I.V., Afanas'yeva O.G. Traditsionnaya meditsina, 2011, no. S5 (28), pp. 388–393. (in Russ.).
Shilova I.V. Khimicheskiy sostav i nootropnaya aktivnost' rasteniy flory Sibiri [The chemical composition and nootropic activity of plants of the flora of Siberia], Tomsk, 2010, 236 p. (in Russ.).
Shilova I.V., Samylina I.A., Suslov N.I. Razrabotka nootropnykh sredstv na osnove rasteniy Sibiri [Development of nootropic drugs based on Siberian plants], Tomsk, 2013, 268 p. (in Russ.).
Mustafin R.N., Suslov N.I., Shilova I.V., Kuvacheva N.V. Eksperimental'naya i klinicheskaya farmakologiya, 2010, vol. 73, no. 1, pp. 16–19. (in Russ.).
Mustafin R.N., Shilova I.V., Suslov N.I., Bakibayev A.A. Vestnik Karagandinskogo universiteta. Seriya Khimiya, 2012, vol. 68, no. 4, pp. 19–23. (in Russ.).
Shilova I.V. Kuvacheva N.V. Meditsina v Kuzbasse, 2009, Special issue no. 3, pp. 188. (in Russ.).
Minayeva V.G. Lekarstvennyye rasteniya Sibiri [Medicinal plants of Siberia: 5th ed., Rev. and add], Novosibirsk, 1991, 428 p.
Shilova I.V., Krasnov Ye.A., Korotkova Ye.I., Nagayev M.G., Lukina A.N. Khimiko-farmatsevticheskiy zhurnal, 2006, vol. 40, no. 12, pp. 22–24. DOI: https://doi.org/10.30906/0023-1134-2006-40-12-22-24 (in Russ.).
Suslov N.I., Shilova I.V., Provalova N.V., Aksinenko S.G., Deveykina A.P. Voprosy biologii, meditsiny i farmatsev-ticheskoy khimii, 2008, no. 6, pp. 47–50. (in Russ.).
Gorbacheva A.V., Aksinenko S.G., Pashinskiy V.G. Labaznik vyazolistnyy v fitoterapii vospalitel'nykh protsessov [Plastifolium in the phytotherapy of inflammatory processes], Tomsk, 2008, 304 p. (in Russ.).
Amel'chenko V.P., Shilova I.V., Kuvacheva N.V. Rastitel'nyye resursy, 2009, vol. 45, no. 2, pp. 23–31. (in Russ.).
Gosudarstvennaya farmakopeya RF [State Pharmacopoeia of the Russian Federation: 13th ed.], Moscow, 2015, 1004 p. (in Russ.).
Shilova I.V., Khoruzhaya T.G., Samylina I.A. Khimiko-farmatsevticheskiy zhurnal, 2013, vol. 47, no. 10, pp. 29–33. DOI: 10.30906/0023-1134-2013-47-10-41-44 (in Russ.).
GSO 8487-2003. Standartnyye obraztsy sostava grafitovogo kollektora mikroprimesey. Komplekt SOG-37 [GSO 8487-2003. Standard samples of the composition of the graphite collector of microimpurities. Set SOG-37], Yekaterinburg, 2003. (in Russ.).
STO TGU 048-2012. Porody gornyye. Opredeleniye elementnogo sostava metodom mass-spektrometrii s induktivno svyazannoy plazmoy [STO TSU 048-2012. The rocks are mountain. Determination of elemental composition by induc-tively coupled plasma mass spectrometry], Tomsk, 2012, 22 p. (in Russ.).
Shilova I.V., Suslov N.I., Otmakhov V.I., Zibareva L.N., Samylina I.A., Mazin Ye.V., Petrova Ye.V., Babushkina M.S., Kovaleva T.Yu., Kuskova I.S., Krapivin A.V. Khimiko-farmatsevticheskiy zhurnal, 2016, vol. 50, no. 10, pp. 27–32. DOI: 10.30906/0023-1134-2016-50-10-27-32 (in Russ.).
Dobrovol'skiy V.V. Osnovy biogeokhimii [Fundamentals of biogeochemistry], Moscow, 2003, 342 p. (in Russ.).
Semenov A.A. Ocherk khimii prirodnykh soyedineniy [Essay on the chemistry of natural compounds], Novosibirsk, 2000, 664 p. (in Russ.).
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