COMPARATIVE EVALUATION OF THE IRON-CHELATING PROPERTIES, ANTIRADICAL AND TOTAL ANTIOX-IDANT ACTIVITY OF EXTRACTS FROM THE RAW MATERIAL OF PHYTOPREPARATIONS OF COMMON ME-DICINAL HERBS
UDC 615.322:615.27:577.13
Abstract
The paper presents results of the comparative study of the iron-chelating potential and antioxidant activity of the raw material of phytopreparations and analysis of correlations between these activities and the content of phenolic compounds as the most important plant antioxidants. The total content of phenolic compounds was determined by the Folin-Chokalteu method, che-lating activity was evaluated using the ferrozine method, antiradical activity was determined by DPPH assay, and total antioxidant (reducing) capacity was assessed by the phosphomolybdenum method. A strong positive correlation was found between the con-tent of phenolic compounds and all the parameters of antioxidant properties of the phytopreparations. The analysis of the dataset (total phenolics, chelating, antiradical and reducing activities) allows arranging the phytopreparations in the order: Origani herba > Uvae Ursi folia, Hyperici herba > Helichrysi arenarii flores > Millefolii herba > Equiseti arvensis herba > Plantaginis majoris folia > Chamomillae flores > Calendulae flores > Urticae folia. Phytopreparations Origani herba, Uvae Ursi folia, and Hyperici herba are demonstrated the highest chelating activity and antioxidant potential. These results can be used as a basis for further studies of chelating and antioxidant properties of medicinal plant raw material.
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