COMPOSITION OF LIPOPHILIC COMPONENTS OF CARAGANA JUBATA (PALL.) POIR. AND INHIBITORY ACTIV-ITY AGAINST THE MAIN PROTEASE OF SARS-COV-2
UDC 547.9:582.284.5
Abstract
The composition of the lipophilic components of the Caragana jubata (Pall.) Poir. was studied. Acid and neutral components were identified using gas-liquid chromatography with mass spectrometric detection. Hexane and methyl tert-butyl ether (MTBE), which has all the advantages of diethyl ether, but is devoid of its disadvantages, were used as the raw material extractants. As a result, comparison with databases triterpene, phenolcarboxylic and aliphatic acids with a chain length of 8 to 30 carbon atoms, including saturated, unsaturated and dibasic acids were discovered. More than 200 triterpene and aliphatic components of the unsaponifiable residue and acid fractions have been identified. Previously, unsaponifiable residues and acids of lipophilic extracts were practically not studied. Only components of water and alcohols extracts of the genus Caragana have been studied in detail. For bioactivity testing, 20 samples of the whole extracts with various solvents were prepared. Hexane, MTBE, MTBE after extraction with hexane, ethanol, water, aqueous ethanol 70%, aqueous ethanol 40%, ethanol after extraction with hexane and MTBE, water after extraction with hexane, MTBE and ethanol were used. The only of the studied samples shows inhibitory activity against the main protease of SARS-CoV-2. It was extract obtained by MTBE after extraction with hexane.
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