COMPONENT COMPOSITION AND SOME FEATURES OF BIOLOGICAL ACTIVITY OF CUSCUTA L.
UDC 547.814.5:582.942(470.638)
Abstract
The review summarizes data on the taxonomy, distribution, component composition and main types of biological activity of Cuscuta L., the most widespread in Russia. Host plant volatiles have been shown to play an important role for the parasitic plant Cuscuta in host selection. Large-scale interplant protein translocation has been discovered that plays an important role in interactions between host plant and dodder and even between hosts connected by a dodder bridge. Currently, biologically active compounds of parasites of the genus Cuscuta L. have been studied in detail. The diverse chemical composition directly correlates with certain types of pharmacological activity. Data on the chemical composition of the main groups of Cuscuta metabolites are summarized, indicating specific compounds. The main classes of analyzed objects were: flavonoids, phenolic acids, alkaloids, lignans, steroids, fatty acids, polysaccharides, resin glycosides and volatile oils. The diverse chemical composition directly correlates with certain types of pharmacological activity: estrogenic, hepatoprotective, cytotoxic, hypoglycemic, antimicrobial, antitumor, antioxidant. Antifibrotic and antiosteoporotic effects were also studied. The information presented in the review shows that plants of the genus Cuscuta are promising for further study.
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Ivanov A.L. Flora Predkavkaz'ya i yeyo genezis. [Flora of the Ciscaucasia and its genesis]. Stavropol', 1998, 290 p. (in Russ.).
Bazdyrev G.I. Sornyye rasteniya i mery bor'by s nimi v sovremennom zemledelii: uchebnoye posobiye dlya vuzov. [Weeds and measures to combat them in modern agriculture: a textbook for universities]. Moscow, 1993, pp. 123–125. (in Russ.).
Nikiticheva Z.I. Zhizn' rasteniy. Tsvetkovyye rasteniya. [Life of plants. Flowering plants]. Moscow, 1981, vol. 5-2, pp. 389–390. (in Russ.).
Saini P., Mithal R., Menghani E. Int. J. Sci. Eng. Res., 2015, vol. 69, no. 12, pp. 951–959.
Zhuk A.V. Strategiya povilik (Cuscuta L.) vo vzaimootnosheniyakh s khozyayevami: avtoref. diss. … kand. biol. nauk. [Strategy of dodder (Cuscuta L.) in relationships with hosts: author's abstract. diss. … candidate of biological sciences]. St. Petersburg, 2000, 22 p. (in Russ.).
Sosudistyye rasteniya sovetskogo Dal'nego Vostoka [Vascular plants of the Soviet Far East], ed. S.S. Kharkevich. St. Petersburg, 1995, vol. 7, 395 p. (in Russ.).
Jhu M.Y., Sinha N.R. Front Plant Sci., 2022, vol. 13, 1086384. https://doi.org/10.3389/fpls.2022.1086384.
Yoshida S., Cui S., Ichihashi Y., Shirasu K. Annu Rev Plant Biol., 2016, vol. 67, pp. 643–667. https://doi.org/10.1146/annurev-arplant-043015-111702.
Vaughn K.C. Protoplasma, 2002, vol. 219, no. 3-4, pp. 227–237. https://doi.org/10.1007/s007090200024.
Vaughn K.C. Protoplasma, 2003, vol. 220, no. 3-4, pp. 189–200. https://doi.org/10.1007/s00709-002-0038-3.
WFO (2023): World Flora Online. URL: http://www.worldfloraonline.org.
Stefanovic S., Krueger, Olmstead L.R.G. Amer. J. Bot., 2002, vol. 89, pp. 1510–1522. https://doi.org/10.3732/ajb.89.9.1510.
Stefanovic S., Austin D.F., Olmstead R.G. Syst. Bot., 2003, vol. 28, pp. 791–806. https://doi.org/10.1043/02-45.1.
Flora yevropeyskoy chasti SSSR. [Flora of the European part of the USSR]. Leningrad, 1981, vol. 5, 380 p. (in Russ.).
Chuzherodnyye vidy na territorii Rossii [Alien species in Russia]. URL: http://www.sevin.ru/invasive/invasion/plants/dodder.html. (in Russ.).
Moskalenko G.P. Karantinnyye sornyye rasteniya Rossii [Quarantine weeds of Russia], 2001, 278 p. (in Russ.).
Nikitin V.V. Sornyye rasteniya SSSR. [Weeds of the USSR]. Leningrad, 1983, 452 p. (in Russ.).
Noureen S., Noreen S., Ghumman S.A., Batool F., Bukhari S.N.A. Iran J. Basic Med. Sci., 2019, vol. 22, no. 11, pp. 1225–1252. https://doi.org/10.22038/ijbms.2019.35296.8407.
Nwokocha M.I., Aigbokhan E.I. Niger J. Bot., 2013, vol. 26, pp. 1–29.
Donnapee S., Li J., Yang X., Ge A.H., Donkor P.O., Gao X.M., Chang Y.X. J. ethnopharmacol., 2014, vol. 157, pp. 292–308. https://doi.org/10.1016/j.jep.2014.09.032.
Doyle G.J. Biology and Environment: Proceedings of the Royal Irish Academy. 1993, pp. 61–67.
Anac E., Kaya I., Tepe I. Proceedings of Joint Workshop of the EWRS Working Groups Weed Management in Arid and Semi-arid Climate and Weed Management Systems in Vegetables, 2011, pp. 4–8. https://doi.org/10.17957/IJAB/15.0266.
Joshi S.K., Sanjay G. Curr Sci., 2003, vol. 84, pp. 1285–1286.
Shimi P., Rezapanah M.R. Iran J. Agric. Sci., 1995, vol. 1, pp. 43–51.
Mescher M.C., Runyon J.B., De Moraes C.M. Plant Signal Behav., 2006, vol. 1, no. 6, pp. 284–286. https://doi.org/10.4161/psb.1.6.3562.
Runyon J.B., Mescher M.C., De Moraes C.M. Plant Physiol., 2008, vol. 146, no. 3, pp. 987–995. https://doi.org/10.1104/pp.107.112219.
Runyon J.B., Mescher M.C., Felton G.W., De Moraes C.M. Plant Cell Environ, 2010, vol. 33, no. 2, pp. 290–303. https://doi.org/10.1111/j.1365-3040.2009.02082.x.
Leusova N.Yu. Osobennosti ekologii rasteniy-parazitov na primere poviliki yaponskoy (Cuscuta japonica Choisy): avtoref. diss. … kand. biol. nauk. [Peculiarities of ecology of parasitic plants on the example of Japanese dodder (Cuscuta japonica Choisy): author's abstract. diss. … candidate of biological sciences]. Blagoveshchensk, 2006, 28 p. (in Russ.).
Chabra A., Monadi T., Azadbakht M., Haerizadeh S.I. J. Ethnopharmacol., 2019, vol. 231, pp. 555–569. https://doi.org/10.1016/j.jep.2018.10.016.
Švubová R., Ovečka M., Pavlovič A., Slováková L., Blehová A. Plant Signal Behav., 2013, vol. 8, no. 5, 24037. https://doi.org/10.4161/psb.24037.
Anikin V.V., Nikel'shparg M.I., Nikel'shparg E.I., Konyukhov I.V. Izvestiya Saratovskogo universiteta. Ser. Khimiya. Biologiya. Ekologiya, 2017, vol. 17, no. 1, pp. 42–47. https://doi.org/10.18500/1816-9775-2017-17-1-42-47. (in Russ.).
Haupt S., Oparka K.J., Sauer N., Neumann S. J. Exp. Bot., 2001, vol. 52, no. 354, pp. 173–177. https://doi.org/10.1093/jexbot/52.354.173.
Birschwilks M., Sauer N., Scheel D., Neumann S. Planta, 2007, vol. 226, no. 5, pp. 1231–1241. https://doi.org/10.1007/s00425-007-0571-6.
Jiang L.J., Qu F., Li Z.H., Doohan D. New Phytol, 2013, vol. 198, pp. 1017–1022. https://doi.org/10.1111/nph.12269.
Shahid S., Kim G., Johnson N.R., Wafula E., Wang F., Coruh C., Bernal-Galeano V., Phifer T., dePamphilis C.W., Westwood J.H. et al. Nature, 2018, vol. 553, pp. 82–85. https://doi.org/10.1038/nature25027.
Smith J.D., Woldemariam M.G., Mescher M.C., Jander G., De Moraes C.M. Plant Physiol., 2016, vol. 172, pp. 181–197. https://doi.org/10.1104/pp.16.00613.
Liu N., Shen G., Xu Y., Liu H., Zhang J., Li S., Li J., Zhang C., Qi J., Wang L., Wu J. Mol. Plant., 2020, vol. 13, no. 4, pp. 573–585. https://doi.org/10.1016/j.molp.2019.12.002.
Shen G., Liu N., Zhang J., Xu Y., Baldwin I.T., Wu J. Proc. Natl. Acad. Sci. USA, 2020, vol. 117, no. 37, pp. 23125–23130. https://doi.org/10.1073/pnas.2009445117.
Ibrahim M., Rehman K., Hussain I., Farooq T., Ali B., Majeed I., Akash M.S.H. Critical Reviews in Eukaryotic Gene Expression, 2017, vol. 27, no. 2, pp. 113–150. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2017019193.
Ahmad A., Tandon S., Xuan T.D., Nooreen Z. Biomed Pharmacother, 2017, vol. 92, pp. 772–795. https://doi.org/10.1016/j.biopha.2017.05.124.
Chiryapkin A.S., Zolotykh D.S., Kodonidi I.P., Glushko A.A., Shcherbakova L.I. Juvenis scientia, 2024, vol. 10, no. 2, pp. 15–33. https://doi.org/10.32415/jscientia_2024_10_2_15-33. (in Russ.).
Ye M., Li Y., Yan Y., Liu H., Ji X. J. Pharm. Biomed. Analysis, 2002, vol. 28, no. 3, pp. 621–628. https://doi.org/10.1016/s0731-7085(01)00672-0.
Hajimehdipoor H.K., Babak M., Amin G., Reza A., Noushin R.S., Maryam H.D. J. Pharm. Sci., 2012, pp. 20–57. https://doi.org/10.1186/2008-2231-20-57.
Zhan W., Zhisheng H. Chin. Tradit. Herb. Drugs, 1998, vol. 9, pp. 115–117.
Petra H., Milan Z., Tomas B., Svajdlenka E., Listy C. Chem. Listy, 2009, vol. 103, no. 3, pp. 243–245.
Ye M., Yan Y., Ni X., Qiao L. J. Chin. Med. Mater., 2001, vol. 24, no. 5, pp. 339–341.
Jafari E., Bahmanzadegan A., Ghanbarian G., Rowshan V. Anal Chem Lett., 2015, vol. 5, pp. 377–384. https://doi.org/10.1080/22297928.2016.1143394.
Löffler C., Czygan F.C., Proksch P. Biochem. Syst. Ecol., 1997, vol. 25, no. 4, pp. 297–303. https://doi.org/10.1016/s0305-1978(97)00015-x.
Du X.M., Kohinata K., Kawasaki T., Guo Y.T., Miyahara K. Phytochem., 1998, vol. 48, pp. 843–850. https://doi.org/10.1016/s0031-9422(97)00990-4.
Guo H., Li J. Zhongguo Zhong Yao Za Zhi, 1997, vol. 22 (1), pp. 38–62.
Yahara S., Domoto H., Sugimura C., Nohara T., Niiho Y., Nakajima Y., Ito H. Phytochemistry, 1994, vol. 37, no. 6, pp. 1755–1757. https://doi.org/10.1016/S0031-9422(00)89605-3.
Pan S., Wang X., Duan W., Yu Z., Zhang L., Liu W. J. Liq. Chromatogr. Relat. Technol., 2013, pp. 2162–2171. https://doi.org/10.1080/10826076.2013.825869.
Xiang S.-X., He Z.-S., Ye Y. Chin. J. Chem., 2001, vol. 19, no. 3, pp. 282–285. https://doi.org/10.1002/cjoc.20010190314.
Ye M., Yan Y., Guo D.A. Rapid Commun Mass Spectrom, 2005, vol. 19, no. 11, pp. 1469–1484. https://doi.org/10.1002/rcm.1944.
Pan S., Wang X., Duan W., Yu Z., Zhang L., Liu W. J. Liq. Chromatog. Relat. Technol., 2014, vol. 37, no. 15, pp. 2162–2167. https://doi.org/10.1080/10826076.2013.825869.
Kwon Y.S., Chang B.S., Kim C.M. Nat. Prod. Sci., 2000, vol. 6, no. 3, pp. 135–138.
Othman R., Awang K., Bakar B.B., Leong S.T., Othman M.R., Annuar M.S.M. The 4th Tropical weed Science Con-ference. Chiang Mai, Thailand, 2013, pp. 16–22. https://doi.org/10.13140/2.1.1708.5763.
Löffler C., Czygan F-C., Proksch P. Biochem. Syst. Ecol., 1997, vol. 25, no. 4, pp. 297–303. https://doi.org/10.1016/s0305-1978(97)00015-x.
Teng J.L. Chinese materia medica. Beijing, 2007, pp. 547–548.
Li W.-L., Zhang Y., Bai J., Xiang Z., Ding J.-X., Ji Y.-B. Bio. Technol.: Indian J., 2013, vol. 8, no. 4, pp. 563–566.
He X.-H., Yang W.-Z., Meng A.-H., He W.-N., Guo D.-A., Ye M. J. Asian Nat. Prod. Res., 2010, vol. 12, no. 11, pp. 934–939. https://doi.org/10.1080/10286020.2010.506434.
Miyahara K., Du X.M., Watanabe M., Sugimura C., Yahara S., Nohara T. Chem. Pharm. Bull., 1996, vol. 44, no. 3, pp. 481–485. https://doi.org/10.1248/cpb.44.481.
Umehara K., Nemoto K., Ohkubo T., Miyase T., Degawa M., Noguchi H. Planta Med., 2004, vol. 70, no. 4, pp. 299–304. https://doi.org/10.1055/s-2004-818939.
Hano C.F., Dinkova-Kostova A.T., Davin L.B., Cort J.R., Lewis N.G. Front. Plant Sci., 2021, vol. 11, pp. 4–6. https://doi.org/10.3389/fpls.2020.630327.
Patent 2354370 (RU). 10.05.2009. (in Russ.).
Zhan W., Zhisheng H. Chin. Tradit. Herb. Drugs, 1998, vol. 9, pp. 115–117.
Tsai Y.C., Lai W.C., Du Y.C., Wu S.F., El-Shazly M, Lee C.L., Yen M.H., Hou M.F., Wu Ya.C., Chang F.R. J. Nat. Prod., 2012, vol. 75, pp. 1424–1431. https://doi.org/10.1021/np200974e.
Yahara S., Domoto H., Sugimura C., Nohara T., Niiho Y., Nakajima Y., Ito H. Phytochemistry, 1994, vol. 37, no. 6, pp. 1755–1757. https://doi.org/10.1016/S0031-9422(00)89605-3.
Ye M., Yan Y., Ni X., Qiao L. J. Chin. Med. Mater., 2001, vol. 24, no. 5, pp. 339–341.
Sayed S.M.A., Alseekh S., Siems K., Fernie A.R., Luyten W., Schmitz-Linneweber C., Saul N. Nutrients. 2022, vol. 14, no. 19, 4199. https://doi.org/10.3390/nu14194199.
Fedotova V.V. Chelovek i yego zdorov'ye, 2022, vol. 25, no. 2, pp. 97–104. https://doi.org/10.21626/vestnik/2022-2/10.
MacKay D.S., Gebauer S.K., Eck P.K., Baer D.J., Jones P.J. Am. J. Clin. Nutr., 2015, vol. 101, no. 3, pp. 432–439. https://doi.org/10.3945/ajcn.114.095356.
Zhelev Z.H., Stanilova S., Carpenter B. Biochem. Biophys. Res. Commun, 1994, vol. 202, pp. 186–196. https://doi.org/10.1006/bbrc.1994.1911.
Leusova N.Yu., Nekrasov E.V. Byulleten' fiziologii i patologii dykhaniya, 2004, no. 19, pp. 87–93. (in Russ.).
Kakharova K.A., Khashimova Z.S., Sagdiyev N.Zh. Trudy mezhdunarodnogo simpoziuma Fundamental'nyye i pri-kladnyye problemy nauki. 2014, vol. 3, pp. 122–128. (in Russ.).
Kakharova K.A., Khashimova Z.S., Sagdiyev N.Zh. Yevraziyskiy Soyuz Uchenykh. Biologicheskiye nauki, 2016, vol. 3, no. 24, pp. 40–43. (in Russ.).
Garcia R., Pena G., Raul C. Biochem. Syst. Ecol., 1995, vol. 23, no. 5, pp. 571–572.
Chang F.R., Hayashi K., Chua N.H., Kamio S., Huang Z.Y., Nozaki H., Wu Y.C. J. Nat. Prod., 2005, vol. 68, no. 7, pp. 971–973. https://doi.org/10.1021/np050121i.
Yen F.L., Wu T.H., Lin L.T., Lin C.C. J. Ethnopharmacol., 2013, vol. 111, no. 1, pp. 123–128. https://doi.org/10.1016/j.jep.2006.11.003.
Kim J.S., Koppula S., Yum M.J., Shin G.M., Chae Y.J., Hong S.M., Lee J.D., Song Min D. Pharmaceutical Biology, 2017, vol. 55, no. 1, pp. 1909–1919. https://doi.org/10.1080/13880209.2017.1340965.
Nicoloff G., Blazhev A., Petrova C., Christova P. Clin. Dev. Immunol., 2004, vol. 11, no. 1, pp. 61–66. https://doi.org/10.1080/10446670410001670517.
Biswas S.K., Chowdury A., Das J., Karmaker U.K. Int. J. Pharmacol., 2012, vol. 8, no. 5, pp. 422–427. https://doi.org/10.3923/ijp.2012.422.427.
Yang H.M., Shin H.K., Kang Y.H., Kim J.K. Journal of Medicinal Food, 2009, vol. 12, pp. 85–92. https://doi.org/10.1089/jmf.2007.0665.
Yang L., Chen Q., Wang F., Zhang G. Journal of Ethnopharmacology, 2011, vol. 135, no. 2, pp. 553–560. https://doi.org/10.1016/j.jep.2011.03.056.
Ghazanfari T., Naseri M., Shams J., Rahmati B. Food Agric Immunol, 2013, vol. 24, pp. 87–94. https://doi.org/10.1080/09540105.2011.648608.
Zeraati F., Zamani A., Goodarzi M.T., Hashjin S.M.M., Razzaghi K. Iran J. Med. Sci., 2015, vol. 35, pp. 310–314.
Karimi Dermani F., Saidijam M., Najafi R., Moradkhani S., Mohammadzaheri Z., Beiranvand N., Mohammadi S., Shabab N., Kalvandi R., Zeraati F. Avicenna J. Phytomed., 2021, vol. 11, no. 3, pp. 258–268.
Zhao Q., Liu Y., Wang X., Zhu Y., Jiao Y., Bao Y., Shi W. Ecotoxicol Environ Saf., 2023, vol. 255, 114831. https://doi.org/10.1016/j.ecoenv.2023.114831.
Zhao Q., Liu Y., Chuo Y., Wang X., Jiao Y., Shi W., Bao Y. Ecotoxicol Environ Saf., 2024, vol. 275, 116253. https://doi.org/10.1016/j.ecoenv.2024.116253.
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