CHEMICAL COMPOSITION OF PEROVSKIA ANGUSTIFOLIA ROOTS COMPONENTS AND THEIR ANTIMICROBIAL ACTIVITY

UDC 615.322:547.913+543.544.45

  • Muhammadzhon Uktam ugli Zhuraev Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz Email: muhammadjon_jurayev@mail.ru
  • Khayrulla Mamadievich Bobakulov Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz, National Research University "Tashkent Institute of Irrigation and Agricultural Mechanization Engineers" Email: khayrulla@rambler.ru
  • Oydinkhon Karimkhon Qizi Askarova Namangan Institute of Engineering and Technology Email: oydinasqarova90@gmail.com
  • Dilmurodjon Burkhonjon Ugli Turdaliev Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz Email: turdaliyevdilmurodjon74@gmail.com
  • Sabirzhan Anarmatovich Sasmakov Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz Email: sasmakov@web.de
  • Erkin Khozhayakbarovich Botirov Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz Email: botirov-nepi@mail.ru
  • Shakhnoz Sadykovna Azimova Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz Email: genlab_icps@yahoo.com
DOI_disc_logo https://doi.org/10.14258/jcprm.20260115799
Keywords: Perovskia angustifolia Kudr., roots, essential oil, GC-MS analysis, cryptotanshinone, caffeic and rosmarinic acids, antimicrobial activity

Abstract

The component composition of the essential oil (EO) obtained by hydrodistillation and hexane extract of the roots of the plant Perovskia angustifolia Kudr., growing in the territory of the Namangan region (Kamchik pass) of the Republic of Uzbekistan, was studied. In total, 52 compounds were characterized in the composition of the essential oil, which is 88.6% of the total amount of oil, and in the hexane extract there were 15 substances, which are 74.0% of the total amount of the extract. Sesquiterpenes and oxidized sesquiterpenes predominate in the composition of the EO. The major components of the EO are aromadendren, ledol, spathulenol, (E)-β-farnesene, tau-cadinol. The dominant components in the hexane extract were oxidized diterpenes, sesquiterpenes and compounds of other classes, and the major components were ferruginol, di(ethylhexyl) phthalate, aromadendren and salvicanol.

Three individual phenolic compounds were isolated from various fractions of the 80% alcoholic extract of P. angustifolia roots, which were identified with cryptotanshinone, caffeic and rosmarinic acids based on the study of 1H, 13C NMR, HSQC and HMBC spectra.

The antibacterial and antifungal effects of the root extracts, cryptotanshinone, rosmarinic and caffeic acids were studied using the disk diffusion method in agar. The results of in vitro tests showed that Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa are sensitive to the action of all the studied samples to varying degrees. The greatest antibacterial effect is observed in chloroform and 80% ethanol extract of roots and rosmarinic acid with an inhibition zone diameter of 18.08±0.12 mm in relation to the gram-positive bacterium S. aureus. All the studied samples were inactive against Escherichia coli and Candida albicans.

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Author Biographies

Muhammadzhon Uktam ugli Zhuraev, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz

basic doctoral student of the laboratory of chemistry of terpenoids and phenolic compounds

Khayrulla Mamadievich Bobakulov, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz, National Research University "Tashkent Institute of Irrigation and Agricultural Mechanization Engineers"

Candidate of Chemical Sciences, Head of the Laboratory of Physical Research Methods

Oydinkhon Karimkhon Qizi Askarova, Namangan Institute of Engineering and Technology

Lecturer, Department of Chemical Engineering

Dilmurodjon Burkhonjon Ugli Turdaliev, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz

Junior Researcher, Molecular Genetics Laboratory

Sabirzhan Anarmatovich Sasmakov, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz

Doctor of Biological Sciences, Senior Researcher, Molecular Genetics Laboratory

Erkin Khozhayakbarovich Botirov, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz

Doctor of Chemical Sciences, Professor, Head of the Laboratory of Chemistry of Terpenoids and Phenolic Compounds

Shakhnoz Sadykovna Azimova, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances AS RUz

Doctor of Biological Sciences, Professor, Head of the Molecular Genetics Laboratory

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Published
2026-03-08
How to Cite
1. Zhuraev M. U. ugli, Bobakulov K. M., Askarova O. K. Q., Turdaliev D. B. U., Sasmakov S. A., Botirov E. K., Azimova S. S. CHEMICAL COMPOSITION OF PEROVSKIA ANGUSTIFOLIA ROOTS COMPONENTS AND THEIR ANTIMICROBIAL ACTIVITY // Chemistry of plant raw material, 2026. № 1. P. Online First. URL: https://journal.asu.ru/cw/article/view/15799.
Issue
No 1 (2026): Online First
Section
Low-molecular weight compounds

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