TECHNOLOGICAL ASPECTS OF OBTAINING AND RHEOLOGICAL PROPERTIES OF A SOFT DOSAGE FORM OF GUANIDINE PECTIN WITH POLYFUNCTIONAL BIOLOGICAL ACTIVITY
UDC 541.64: 615.45
Abstract
The article presents the technology of obtaining a soft dosage form of guanidine pectin synthesized at the Institute of Bioorganic Chemistry, containing 0.5% guanidine pectin as an active substance in the form of hydrochloride, with a guanidine content of 24.7%, a pKα value of 9.7±0.1 and a substitution degree of 90 mol%, possessing antimicrobial and wound-healing properties. To obtain a soft dosage form for local use, guanidine pectin was included in the gel base. Comparative studies of the rheological properties of gel bases with carbopol concentrations of 0.5, 1.0 and 1.5% and guanidine pectin gel were carried out. The results of the study showed that the dynamic viscosity of the gel base directly depends on the concentration of carbopol. In the case of a carbopol content of more than 0.5%, a change in the rheological properties of the gel bases occurs, which do not meet the necessary requirements. It was found that when adding 0.5% guanidine pectin to the gel base, the dynamic viscosity coefficient of the structured system decreases slightly from 4.5 to 4.3 Pa·s. However, increasing the concentration of guanidine pectin to 0.75 and 1.0% contributes to a sharp drop in the dynamic viscosity of the gel base. The developed gel containing 0.5% guanidine pectin does not delaminate or change color for 27 months, retains its shape with a dynamic viscosity coefficient of (4.5 Pa·s) at a shear rate of 0.33 s-1, i.e. it is stable during natural storage.
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