GLUCOSINOLATES: CHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY (REVIEW)
UDC 615.1:547.9:577.1
Abstract
Currently, in the domestic scientific literature there is no structured information combining data on glucosinolates (CLS) as a class of biologically active compounds (BAC) that is promising for research. The article provides a systematic material on the chemical characteristics of CLS, which unite sulfur-containing glycosides of representatives of the cabbage family (Brassicaceae), chemical classification and possible pathways for chemical synthesis of CLS. The metabolism and biological activity of CLS are discussed separately. It is shown that under the action of myrosinase, active metabolites are formed, in particular, isothiocyanates (ITC), which are the main products of CLS hydrolysis. An analysis of literary data on the antitumor and cardioprotective activities of CLS and their metabolites is presented. In conclusion, some features of CLS extraction from natural sources and the main methods of their analysis are discussed. It is concluded that in the future, with the accumulation of sufficient experimental and theoretical material, this class of compounds can be considered as prodrugs for the treatment of nosologies with high medical and social significance.
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