IN VITRO STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF SOME MEDICINAL AND EDIBLE PLANTS GROWING IN RUSSIA

  • Katerina Kalinkevich Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow, 117545 Email: katerina_kalinkevich@agri.ru
  • Vladimir Evgen'evich Karandashov Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow, 117545 Email: vladimir_karandashov@agri.ru
  • Leonid Romanovich Ptitsyn Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow, 117545 Email: leonid_ptitsyn@agri.ru
DOI_disc_logo https://doi.org/10.14258/jcprm.1301113
Keywords: anti-inflammatory, plant extracts, TNF-α assay, PGE2 assay

Abstract

The effects of the ethanolic extracts of 105 plants used in Russian traditional medicine, 26 vegetables and fruits and 2 mushrooms on the release of tumor necrosis factor α (TNF-α) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated differentiated human acute monocytic leukemia THP-1 cells were studied using TNF-α and PGE2 assays, respectively. We found that 16 plant extracts inhibited TNF-α production and 15 extracts decreased PGE2 release in the cells in a concentration-dependent manner. Guilder rose, tansy, shrubby cinquefoil, wintergreen and prince's pine, the last two of which belong to the Pyrolaceae family, notably inhibited the levels of both of the inflammatory mediators.

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Author Biographies

Katerina Kalinkevich, Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow, 117545
Researcher
Vladimir Evgen'evich Karandashov, Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow, 117545
Ph.D., Senior Research Fellow
Leonid Romanovich Ptitsyn, Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow, 117545
Laboratory Head, Ph.D., Associate Professor, tel.; +7 (495) 315-23-30, fax: +7 (495) 315-06-40

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Published
2013-03-20
How to Cite
1. Kalinkevich K., Karandashov V. E., Ptitsyn L. R. IN VITRO STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF SOME MEDICINAL AND EDIBLE PLANTS GROWING IN RUSSIA // Chemistry of plant raw material, 2013. № 1. P. 113-118. URL: https://journal.asu.ru/cw/article/view/jcprm.1301113.
Issue
No 1 (2013)
Section
Low-molecular weight compounds

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