THE STUDY OF SYNTHESIS, STRUCTURE AND PROPERTIES OF FLAVONOID COMPLEXES WITH METAL IONS. 2. THE OPTIMIZATION OF THE ZINC COMPLEXATION WITH DIHYDROQUERCETIN IN AQUEOUS SOLUTIONS
Abstract
The kinetics of complexation zinc with dihydroquercetin in aqueous solutions have been studied for optimization the reaction. The dihydroquercetin and zinc ion concentrations were determined by spectrophotometry and titrimetric methods, respectively. The chemical formule C30H26O16Zn with Zn 9,2% and the stoichiometry of the biligand complex were determined by elemental analysis and energy-dispersive X-ray spectroscopy analysis. It was found that the initial ratio of Zn2+ and dihydroquercetin equal 2 : 1 mol and pH 5,11 were the optimal for maximum yield of the product. The reaction proceeded rapidly, the formation of bulk of the product and the stoichiometry of metal and flavonoid in compound were determined at first minute of synthesis. The begining of the complexation was observed when adjusting the pH to 5,1–6,0 when zinc salts containing anions of strong acids were used as a reagents.Downloads
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Макашев Ю.А., Шаронов В.П., Грачев С.А., Миронов В.Е., Макашева И.Е. Кинетика комплексообразования некоторых переходных металлов с кверцетином и морином // Известия АН СССР. Сер. Химическая. 1976. №4. С. 907–909.
Malesev D., Kuntic V. Investigation of metal-flavonoid chelates and the determination of flavonoids via flavonoid complexing reactions (rewiew) // J. Serb. Chem. Soc. 2007. Vol. 72, №10. Pp. 921–939.
Макашев Ю.А., Шаронов В.П., Миронов В.Е., Макашева И.Е., Блохин В.В. О скоростях образования кверце-тиновых и мориновых комплексов переходных металлов // Журнал общей химии. 1975. Т. 45, №12. С. 2748.
Макашева И.Е., Головкина М.Т. Взаимодействие кверцетина с ионами меди (II) в водно-спиртовых растворах // Журнал общей химии. 1973. Т. 43, №7. С. 1640–1645.
Макашева И.Е., Мирзаева Л.К., Головкина М.Т. Спектрофотометрическое исследование взаимодействия кверцетина с цинком // Журнал общей химии. 1974. Т. 44, №7. С. 1570–1575.
Столповская Е.В., Трофимова Н.Н., Бабкин В.А., Костыро Я.А. Биологическая активность комплексов дигид-рокверцетина с ионами двухвалентных металлов // Новые достижения в химии и химической технологии рас-тительного сырья : мат. V Всерос. конф. с международным участием. Барнаул, 2012. С. 273.
Трофимова Н.Н., Бабкин В.А., Вакульская Т.И., Чупарина Е.В. Исследование методов синтеза, строения и свойств комплексов флавоноидов с ионами металлов. Сообщение 1. Синтез и установление строения ком-плексов и солей дигидрокверцетина с цинком, медью (II) и кальцием в водных растворах // Химия раститель-ного сырья. 2012. №2. С. 51–62.
Государственная фармакопея СССР: Вып. 2: Общие методы анализа. Лекарственное растительное сырье. 11-е изд., доп. М., 1989. 400 с.
De Souza Rubens F.V., De Giovani Wagner F. Synthesis, spectral fnd electrochemical properties of Al(III) and Zn(II) complexes with flavonoids // Spectrochimica Acta. Part A. 2005. Vol. 61, №9. Pp. 1985–1990.
Костюк В.А., Потапович А.И. Биорадикалы и биоантиоксиданты. Минск, 2004. 174 с.
Головкина М.Т., Караван С.В., Покровская М.В. О взаимодействии кверцетина с ионами Fe(II) и Fe(III) // Журнал органической химии. 1974. Т. XLIV, вып. 11. С. 2569–2572.
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