ANTIMICROBIAL ACTIVITY OF SECONDARY METABOLITES ISOLATED FROM THE TOADFLAX HERB (LINARIA VULGARIS MILL.)

UDC 615.322

DOI_disc_logo https://doi.org/10.14258/jcprm.20240414795
Keywords: Linaria vulgaris, toadflax, polyphenols, flavonoids, phenolic acids, antibacterial activity, antifungal activity, pectolinarin, p-coumaric acid

Abstract

The widespread and inappropriate use of antibiotics has led to the emergence of new multidrug-resistant (MDR) strains of microorganisms, rendering many currently available drugs ineffective. Thus, there is a growing need to develop new antimicrobial agents that can reduce antibiotic use and counter the development of resistance. According to previous studies, polyphenols are able to exhibit pronounced antimicrobial activity. Linaria vulgaris Mill. is one of the promising representatives of the genus Linaria, the chemical composition of which is represented by such classes of metabolites as phenolic acids, flavonoids, phenolic glycosides, alkaloids and iridoids. As a result of the present study, 6 compounds belonging to the classes of flavonoids and phenolic acids were isolated from the herb L. vulgaris, and their activity against S. aureus, C. albicans and E. coli was studied. Among all the isolated compounds, p-coumaric acid showed the greatest antimicrobial activity, the minimum inhibitory concentration (MIC) of which was 250, 500 and 1000 μg/ml against C. albicans, E. coli and S. aureus, respectively.

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Author Biographies

Andrey Kenneth Whaley, Saint-Petersburg State Chemical and Pharmaceutical University

Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Pharmacognosy

Anastasia Olegovna Whaley , Saint-Petersburg State Chemical and Pharmaceutical University, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Candidate of Pharmaceutical Sciences, Junior Researcher of the Department of Pharmacognosy, Senior Researcher of the Laboratory of Cellular Mechanisms of Blood Homeostasis

Tatyana Vladimirovna Bombela, Perm State Pharmaceutical Academy

Doctor of Pharmaceutical Sciences, Associate Professor, Professor of the Department of Botany and Pharmaceutical Biology

Olga Alexandrovna Korotkova, Perm State Pharmaceutical Academy

Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Botany and Pharmaceutical Biology

Alexandra Sergeevna Chashchina, Perm State Pharmaceutical Academy

Laboratory Assistant of the Department of Botany and Pharmaceutical Biology

Valentina Vasilyevna Novikova , Perm State Pharmaceutical Academy

Doctor of Pharmaceutical Sciences, Associate Professor, Head of the Department microbiology

Vitaly Olegovich Vasiliev, Perm State Pharmaceutical Academy

Postgraduate student of the Department of Microbiology

Vladimir Gennadievich Luzhanin, Perm State Pharmaceutical Academy

Candidate of Biological Sciences, Associate Professor, Rector, Head of the Department of Botany and Pharmaceutical Biology

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Published
2024-12-08
How to Cite
1. Whaley A. K., Whaley A. O., Bombela T. V., Korotkova O. A., Chashchina A. S., Novikova V. V., Vasiliev V. O., Luzhanin V. G. ANTIMICROBIAL ACTIVITY OF SECONDARY METABOLITES ISOLATED FROM THE TOADFLAX HERB (LINARIA VULGARIS MILL.) // Chemistry of plant raw material, 2024. № 4. P. 287-296. URL: https://journal.asu.ru/cw/article/view/14795.
Issue
No 4 (2024)
Section
Low-molecular weight compounds

Copyright (c) 2024 chemistry of plant raw material

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