OPTIMIZATION OF THE PROCESS OF BIOLOGICALLY – ACTIVE BETULIN DIPROPIONATE PRODUCTION FROM OUTER BIRCH BARK
UDC 547.914+581.192.2
Abstract
The aim of this work was the mathematical modeling and selection of optimal regimes for the process of biologically active betulin dipropionate production based on the treatment of birch bark by propionic acid. In order to achieve this aim, two variable factors of the process were varied: X1 – the average size of bark particles (3.5 and 15.0 mm); X2 – the duration of the process. The output parameters were: Y1 – product yield (as a percentage by mass of the absolutely dry bark); Y2 – mass fraction of betulin dipropionate in the product (in percent); Y3 – the yield of betulin dipropionate as a percentage by mass of the absolutely dry bark. For mathematical processing of the results, the Statgraphics Centurion XVI package, the DOE block, the Multi-Factor Categorical procedure were used.
It was established by experimental and computational methods that the optimal conditions for obtaining the product with the highest content of betulin dipropionate are as follows: a ratio liquid/solid of 20, an average size of bark particles of 3.5 mm, a time of 8–12 hours.
The structure of betulin dipropionate, obtained under optimal conditions, was confirmed by physicochemical methods, the purity of the product was 95%. Due to its low toxicity and valuable pharmacological properties the betulin dipropionate has prospects for use in medicine.
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