CHEMICAL PROFILE AND BIOLOGOCAL ACTITITY OF FLAVONOIDS AND PHENYLPROPANOIDS FROM NEPETA CATARIA L. (LAMIACEAE) CULTIVATED IN THE EASTERN SIBERIA
Abstract
A chemical investigation of Nepeta cataria L. (Lamiaceae), cultivated in the Eastern Siberia (Buryatia Republic, Russia) was realized. Thirty-one compounds were isolated using different chromatographic techniques including components detected in species for the first time: chrisoeriol, cirsilineol, isorhoifolin, tilianin, acacetin-7-O-glucuronide, linarin, scolimoside, caftaric, cichoric and phaselic acids. In the course of studying the distribution of phenolic compounds in organs of N. cataria it was shown first that the accumulation of compounds was characterized by the organ specific manner. Caffeoyltartronic acid was a dominant compound in leaves (21,59 mg·g-1) and stems (16.70 mg·g-1), as well as rosmarinic acid dominated in roots (36,93 mg·g-1) and flowers (7,67 mg·g-1). The investigation of the biological activity of N. cataria dry extract showed the presence of anti-inflammatory properties. For the first time the anti-inflammatory activity of two marker compounds of N. cataria like luteolin-7-O-(6''-glucurono)-glucoside and caffeyltartronic acid was revealed, and the efficiency of the latter compound was the highest.
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