CHEMICAL MODIFICATION AND BIOLOGICAL ACTIVITY OF NATURAL POLYPHENOL - GOSSIPOL
UDC 547.562.1+615
Abstract
The article provides information on obtaining a water-soluble imino derivative of gossypol, which is its complex with barbituric acid. Because of the subsequent chemical modification of gossypol with poly-N-vinylpyrrolidone, a new water-soluble complex was obtained. Some physicochemical parameters of the resulting complex compound were studied. The structure was analyzed using UV and IR spectroscopy. The water-soluble complex of the imine derivative of gossypol with poly-N-vinylpyrrolidone can be formed due to the carbonyl groups of the polymer and the functional (OH-, NH-) groups of gossypol. It is assumed that the water of hydration present in poly-N-vinylpyrrolidone plays an important role in the formation of complex compounds. Based on the results of analysis obtained by modern methods of UV and IR spectroscopy, a structural formula of the resulting water-soluble complex was proposed.
The positive inotropic effect of the obtained complex compound on the contractile activity of the papillary muscle of the rat heart was studied for the first time. In all likelihood, the positive inotropic effect of the new water-soluble complex arises as a result of partial activation of potential-dependent Ca2+L-channels in cardiomyocytes and an increase in the supply of Ca2+ ions to cardiomyocytes. Thus, the activation of Ca2+L-channels in the positive inotropic effect of the obtained water-soluble complex was proved, as well as the effect of other Ca2+ transport systems on the change [Ca2+]in concentration.
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